前列腺癌相关长链非编码RNA的研究现状

Research status of long non-coding Rnas associated with prostate cancer

前列腺癌(PCa)患者通常表现为无症状,当症状出现时,多数患者因病情进展至晚期而无法行根治手术,且其中绝大多数患者的肿瘤已发生转移,导致预后不佳及生存期较短。因此,针对PCa现阶段迫切需要探索新的早期诊断方法。长链非编码RNA(lncRNA)是一类转录本长度超过200个核苷酸、无编码蛋白质能力的RNA分子。在癌症中,lncRNA的表达可出现显著异常,并在包括PCa在内的各种癌症的发生与发展中发挥着重要作用。本文简要综述了lncRNA在PCa中的研究进展。

Patients with prostate cancer(PCa)are usually asymptomatic.When symptoms appear,most patients cannot undergo radical surgery due to advanced disease progression,and most of them have metastases,leading to poor prognosis and short survival.Therefore,it is urgent to explore new early diagnos is methods for PCa.Long non-coding RNA(lncRNA)is a class of RNA molecules whose transcript length exceeds 200 nucleotides and have no ability to encode protein.lncRNA expression can be significantly abnormal in cancer,and plays an important role in the occur rence and development of various cancers,including PCa.This paper briefly reviewed the research progress of lncRNA in PCa.