职业紧张对基因测序企业员工抑郁和睡眠的影响

Effect of occupational stress on depression and sleep of gene sequencing enterprise employees

[背景]基因测序行业是技术创新驱动型行业,对员工的自主学习和创新能力要求较高,员工面临较大的职业压力。[目的]了解基因测序企业员工职业紧张、抑郁及睡眠情况,分析职业紧张对二者的影响。[方法]2021年11—12月,采用职业紧张测量核心量表、病人健康问卷中文版、匹兹堡睡眠质量指数量表对34家基因测序企业469名员工职业紧张、抑郁及睡眠情况进行问卷调查。回收有效问卷427份,问卷有效率为91.04%。采用logistic回归模型探索职业紧张与抑郁、睡眠情况间关系。[结果]研究对象职业紧张、抑郁和睡眠障碍发生率分别为27.40%、33.49%、28.10%。不同职业紧张程度组抑郁和睡眠障碍发生率差异均具有统计学意义(P<0.05)。多因素logistic回归分析结果显示:研究对象职业紧张的社会支持维度分值每增加1分,抑郁的发生风险升高至1.206(95%CI:1.117~1.304)倍,睡眠障碍的发生风险升高至1.143(95%CI:1.059~1.233)倍;组织与回报维度分值每增加1分,抑郁的发生风险升高至1.082(95%CI:1.017~1.151)倍;轻度、中度、重度职业紧张者较无职业紧张者抑郁发生风险升高(OR=2.535,95%CI:1.465~4.386;OR=3.774,95%CI:1.809~7.870;OR=3.823,95%CI:1.486~9.837);重度职业紧张者睡眠障碍发生风险较无职业紧张者增高(OR=3.141,95%CI:1.233~8.006)。[结论]基因测序行业员工职业紧张可增加抑郁及睡眠障碍发生风险,企业需采取干预措施并注意防治。

[Background]Gene sequencing industry is an emerging innovation-driven industry.Employees have high requirements for independent learning and innovation ability and face great professional pressure.[Objective]To understand the occupational stress,depression,and sleep of gene sequencing enterprise employees and to analyze the effect of occupational stress on depression and sleep.[Methods]From November to December 2021,occupational stress,depression,and sleep conditions of 469 workers from 34 enterprises in gene sequencing industry were surveyed by Core Occupational Stress Scale(COSS),Patient Health Questionnaire 9(PHQ-9),and Pittsburgh Sleep Quality Index(PSQI).A total of 427 valid questionnaires were recovered with a questionnaire valid response rate of 91.04%.The relationship of occupational stress with depression or sleep was analyzed by logistic regression.[Results]The rates of occupational stress,depression,and sleep disorder were 27.40%,33.50%,and 28.10%,respectively.Significant difference were found in the rates of depression and sleep disorder in different occupational stress groups(P<0.05).The results of logistic regression analysis showed that,for every 1 increase in social support score,the risk of depression increased by1.206(95%CI:1.117-1.304),and the risk of sleep disorder increased by 1.143(95%CI:1.059-1.233).For every 1 increase in organization and reward score,the risk of developing depression increased by 1.082(95%CI:1.017-1.151).Mild,moderate,and severe occupational stress we re all associated with a higher risk of depression in reference to no occupational stress(OR=2.535,95%CI:1.465-4.386;OR=3.774,95%CI:1.809-7.870;OR=3.823,95%CI:1.486-9.837).Severe occupational stress was associated with a higher risk of sleep disorder in reference to no occupational stress(OR=3.141,95%CI:1.233-8.006).[Conclusion]Occupational stress among employees in the gene sequencing industry can increase the risks of depression and sleep disorder.Enterprises need to take intervention measures and pay attention to prevention and treatment.