有机磷阻燃剂对人群健康影响的研究进展

Recent research development on human health associated with organophosphorus flame retardants

有机磷阻燃剂(OPFRs)的污染和健康危害是一个全球关注的问题。本文回顾了近年来OPFRs在暴露评估和健康效应两方面的流行病学证据;概述和比较了全球范围内不同人群经呼吸道和胃肠道暴露于OPFRs的水平以及其在体内的负荷水平;归纳和总结了长期低水平的OPFRs暴露对儿童神经发育、成年人的生殖系统以及甲状腺功能等方面的潜在危害。目前流行病学研究发现中国人群的OPFRs暴露水平相对较低,但食用大米可能是我国人群暴露OPFRs的一个重要途径;以磷酸三(1-氯-2-丙基)酯和三(2-氯乙基)磷酸酯为主的OPFRs具有神经毒性和生殖毒性,同时可能影响成年人的甲状腺功能以及增加儿童气喘和湿疹的发生风险。最后,本文对OPFRs人群暴露和健康效应的未来研究重点提出了展望。

Organophosphorus flame retardants(OPFRs)pollution and its impacts on human health are of global concern.The review briefly reviewed the current state-of-knowledge on exposure assessment and epidemiological evidence of OPFRs-related health effects.Specifically,this paper provided an overview and comparison of the levels of respiratory and gastrointestinal exposure to OPFRs and their body burden in different populations wo rldwide;summarized potential adve rse effects of long-term low-level OPFRs exposure on children’s neurodevelopment,adults’reproductive system,and thyroid function.Available epidemiological studies have revealed that the OPFRs exposure level of Chinese population is low,and rice consumption may be a potential source of exposure to OPFRs;OPFRs such as tris(1-chloro-2-propyl)phosphate(TCIPP)and tris(2-chloroethyl)phosphate(TCEP)have both neurotoxicity and reproductive toxicity,and possibly affect the thyroid function in adults and increase the risk of wheezing and eczema in children.Finally,the future research focus on population exposure and health effects of OPFRs was prospected.