奥美拉唑与兰索拉唑治疗胃食管反流病效果的meta分析

Meta analysis of the Effects of Omeprazole and Lansoprazole in the treatment of Gastroesophageal Reflux Disease

目的系统性评价奥美拉唑、兰索拉唑治疗胃食管反流病的临床疗效,为胃食管反流病临床治疗方案选择提供数据支持。方法依据胃食管反流病、奥美拉唑以及兰索拉唑等主题,检索知网、万方、PubMed、维普、龙源等数据库,筛选并最终纳入文献12篇。其中,观察组采用口服兰索拉唑缓释胶囊治疗,对照组采用口服奥美拉唑肠溶胶囊治疗,对总有效率、不良反应发生率、症状缓解情况、胃镜下愈合率4项指标作系统性分析。结果观察组总有效率明显高于对照组,差异具有统计学意义(OR=7.09,95%CI:3.48~14.46,Z=5.39,P<0.00001);观察组不良反应发生率明显低于对照组,差异具有统计学意义(OR=0.31,95%CI:0.19~0.50,Z=4.83,P<0.00001);观察组症状缓解情况明显优于对照组,差异具有统计学意义(OR=3.64,95%CI:1.97~6.74,Z=4.11,P<0.00001);观察组胃镜下愈合率明显高于对照组,差异具有统计学意义(OR=2.66,95%CI:1.66~4.25,Z=4.09,P<0.00001)。结论相较于奥美拉唑,应用兰索拉唑治疗胃食管反流病疗效更显著,不良反应少,安全可靠,能够有效缓解患者临床症状,促进恢复。

OBJECTIVE To systematically evaluate the clinical efficacy of omeprazole and lansoprazole in the treatment of gastroesophageal reflux disease,aiming to provide data support for the selection of clinical treatment options for gastroesophageal reflux disease.METHODS Based on topics such as gastroesophageal reflux disease,omeprazole and lansoprazole,searched well-known databases such as CNKI,Wanfang,PubMed,Weipu,Longyuan,etc.,screened and finally included 12 articles.Among them,the observation group was treated with oral lansoprazole sustained-release capsules,and the control group was treated with oral omeprazole enteric-coated capsules.The total effective rate,incidence of adverse reactions,symptom relief,and healing rate under gastroscopy were used as four indicators with systematic analysis.RESULTS The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(OR=7.09,95%CI:3.48-14.46,Z=5.39,P<0.00001);the incidence of adverse reactions in the observation group was significantly lower than that of the control group,the difference was statistically significant(OR=0.31,95%CI:0.19-0.50,Z=4.83,P<0.00001);the symptom relief of the observation group was significantly better than that of the control group,and the difference was statistically significant(OR=3.64,95%CI:1.97-6.74,Z=4.11,P<0.00001);the healing rate under gastroscopy in the observation group was significantly higher than that in the control group,and the difference was statistically significant(OR=2.66,95%CI:1.66-4.25,Z=4.09,P<0.00001).CONCLUSION Compared with omeprazole treatment,lansoprazole is more effective in the treatment of gastroesophageal reflux disease,has fewer adverse reactions,is safe and reliable,and can effectively relieve patients’clinical symptoms and promote recovery.