乌鲁木齐市天山区维吾尔族女性围绝经期和绝经后期代谢综合征现况及危险因素分析

Prevalence and risk factors of metabolic syndrome among pre-menopausal and post-menopausal women of Uygur in Tianshan District of Urumqi

目的了解乌鲁木齐市天山区维吾尔族女性围绝经期、绝经后期代谢综合征(MS)现况,分析其危险因素。方法2017年5月在乌鲁木齐市天山区进行横断面调查,采用整群随机抽样方法,对其中4个社区进行问卷调查、体格检查及实验室检查。结果40岁以上维吾尔族女性共计822例,年龄为(50.44±9.16)岁,围绝经期439例,绝经后期383例。40岁以上维吾尔族妇女MS患病率为32.8%,围绝经期为19.1%,绝经后期为48.6%,绝经前后患病率差异有统计学意义(P<0.01)。中心性肥胖、血压、血糖、TG、高密度脂蛋白胆固醇(HDL-C)异常患病率分别为76.6%、40.3%、31.1%、32.7%、7.8%,随着年龄增长腰围异常、血压异常、血糖异常、TG异常、MS均显著增加,差异有统计学意义(均P<0.05),不同年龄段HDL-C异常差异无统计学意义(P>0.05)。MS相关影响因素的logistic回归分析结果显示:绝经与MS显著相关(OR=4.972,95%CI:2.607~9.482,P<0.001),MS其他危险因素有高BMI、糖尿病家族史、重体力活动、吸烟、打鼾。结论乌鲁木齐市天山区维吾尔族绝经后期女性MS患病率较高,随着年龄增长呈显著上升趋势,应加强围绝经期及绝经后期女性教育,及早采取预防和干预措施,合理饮食、控制体重,降低绝经后期MS及心血管疾病的发生风险,提高生活质量。

Objective To investigate the prevalence of metabolic syndrome(MS)among pre-menopausal and post-menopausal women of Uygur in Tianshan District of Urumqi and analyze the risk factors.Methods A cross-sectional survey was carried out in Tianshan District,Urumqi City in May 2017.A cluster random sampling method was used to conduct a questionnaire survey,physical examination and laboratory examination in four communities.Results The number of observation cases of this study was 822.The mean age of the subjects was(50.44±9.16)years old,439 cases of pre-menopausal,383 cases of post-menopause.The prevalence of MS in women over 40 years old was 32.8%,19.1%in perimenopause and 48.6%in post-menopause.The prevalence difference in pre-menopausal and post-menopausal women was statistically significant(P<0.01).The prevalence of central obesity,blood pressure,blood glucose,triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C)were 76.6%,40.3%,31.1%,32.7%and 7.8%,respectively.Abnormal waist circumference,abnormal blood pressure,abnormal blood glucose,abnormal TG and MS levels were significantly increased with increasing age,with a statistically significant difference(all P<0.05).There was no significant difference in HDL-C abnormalities among different age groups(P>0.05).The logistic regression analysis of relative risk factors for MS showed that the MS was associated with menopause significantly(OR=4.972,95%CI:2.607-9.482,P<0.001),and the other risk factors for MS were high BMI,family history of diabetes,heavy physical activity,smoking,and snoring.Conclusion Post-menopausal women are at high-risk of MS,significant upward trend with age.We should strengthen the education of perimenopausal and postmenopausal women,take early prevention and intervention measures,reasonably diet,control weight,reduce the risk of postmenopausal MS and cardiovascular disease,and improve quality of life.