Material basis and mechanism research progress of Curcumae Rhizoma-Sparganii Rhizoma herb pair ameliorates liver fibrosis

Liver fibrosis,a wound healing response induced by multiple pathogenic factors(alcohol,virus,drugs,etc.),is a familiar pathological state in multiple chronic liver diseases(CLD)including non-alcoholic fatty liver disease,virus hepatitis and liver cirrhosis etc[1].Longstanding hepatic fibrosis could result in cirrhosis of liver and even tumor.A recent World Health Organization report estimated that about twenty million human beings have hepatic cirrhosis and/or liver cancer globally,in which 1-2 million people die from hepatic failure every year[2].It is well known that the over-accumulation of extracellular matrix components which secreted by the activation of hepatic stellate cell is the core incident in hepatic fibrosis progress[3].Present evidence indicated that hepatic fibrosis stage is the unique reversible phase,as well as the best treatment phase of CLD.In consequence,it is urgent to exploit effective drugs to intervene liver fibrosis further develop to liver cirrhosis or cancer[4].However,there are currently no effective strategy or drugs for the treatment of liver fibrosis[5].Amazingly,Traditional herbal medicine shows significant curative effects in the treatment of CLD due to its characteristics of multi-ingredients,multi-target points,and multi-signal pathway exert effects[6-8].Among these effective herbal medicines,Curcumae Rhizoma-Sparganii Rhizoma herb pair has excellent performance in treating CLD.