摘要
目的:考察血栓通注射液与黄芪注射液的配伍稳定性。方法:将血栓通注射液与黄芪注射液依照临床使用的质量浓度配伍,分别用5%葡萄糖注射液(5%GS)、10%葡萄糖注射液(10%GS)、0.9%氯化钠注射液(0.9%NS)稀释,考察室温下放置0 h、2 h、4 h、6 h、8 h后配伍溶液的性状、pH值、不溶性微粒、渗透压摩尔浓度以及三七总皂苷的含量等关键指标,综合评价药物配伍后稳定性变化。结果:血栓通注射液与黄芪注射液配伍后8 h内性状、pH值、不溶性微粒、渗透压摩尔浓度及三七总皂苷的含量均无明显变化。结论:血栓通注射液与黄芪注射液配伍后8 h内基本稳定。
Objective: To investigate the compatibility stability of Xueshuantong injection and astragalus injection. Methods:Xueshuantong injection and astragalus injection were diluted with 5% glucose injection(5%GS), 10% glucose injection(10%GS) and 0.9%sodium chloride injection(0.9%NS) according to the mass concentration of clinical use. The properties, pH value, insoluble particles,osmotic molar concentration and the content of total saponins of panax notoginseng were investigated after the compatibility solution was placed at room temperature for 0h, 2h, 4h, 6h and 8h, and the stability of the solution was comprehensively evaluated. Results: The properties, pH value, insoluble particles, osmotic molar concentration and total saponins content of panax notoginseng had no significant changes in 8h after the compatibility of Xueshuantong injection and astragalus injection. Conclusion: Xueshuantong injection and astragalus injection are basically stable within 8h after compatibility.
出处
《大众科技》
2022年第12期49-53,共5页
Popular Science & Technology
基金
梧州市科技计划项目202102011
广西科技基地和人才专项(桂科AD20297068)。
关键词
血栓通注射液
黄芪注射液
葡萄糖注射液
氯化钠注射液
配伍
稳定性
Xueshuantong injection
astragalus injection
glucose injection
sodium chloride injection
compatibility
stability