摘要
Tau蛋白正电子发射断层扫描(PET)脑显像可以直观显示脑组织中tau蛋白的聚集和分布,在tau蛋白病诊断和病情评估中具有积极的临床意义。在阿尔茨海默病(AD)中,tau蛋白PET脑显像已成熟开展。然而在原发性tau蛋白病中,tau蛋白PET脑显像的应用尚处于临床研究阶段。文中在强调规范化tau蛋白PET脑显像技术操作基础上,对常见原发性tau蛋白病(进行性核上性麻痹、皮质基底节变性、额颞叶痴呆,等)的tau蛋白PET脑显像研究进行系统总结,征求各个专家意见后形成本专家共识。旨在规范常见原发性tau蛋白病开展tau蛋白PET脑显像的技术操作,为报告解读提供建议,进一步推动tau蛋白PET脑显像在原发性tau蛋白病中的临床应用。
Tau protein positron emission tomography(PET) imaging could be used to recognize the aggregation and distribution of tau protein in vivo in the patients with tauopathies, which is valuable in disease diagnosis and clinical assessment. In Alzheimer’s disease(AD), tau PET imaging has been successfully applied. However, in the primary tauopathies, the application of tau PET imaging is still in its infancy. A systematic review of the tau PET imaging study in some common primary tauopathies(progressive supranuclear palsy, corticobasal degeneration, frontotemporal dementia, etc.) was conducted,and an expert consensus was formed. This consensus aimed to standardize the operation procedures of tau PET imaging in the common primary tauopathies, and provide suggestions for the report interpretations.Our work will further promote the clinical application of tau PET imaging in primary tauopathies in China.
作者
刘丰韬
鲁佳荧
丁正同
王含
王峰
王振光
王涛
兰晓莉
卢洁
田蓉
孙龙
朱晓冬
吴平
张祥松
张慧玮
李欣忆
邬剑军
金莉蓉
陈玲
胡硕
高识
富丽萍
崔瑞雪
葛璟洁
管一晖
左传涛
王坚
LIU Feng-tao;LU Jia-ying;DING Zheng-tong;WANG Han;WANG Feng;WANG Zhen-guang;WANG Tao;LAN Xiao-li;LU Jie;TIAN Rong;SUN Long;ZHU Xiao-dong;WU Ping;ZHANG Xiang-song;ZHANG Hui-wei;LI Xin-yi;WU Jian-jun;JIN Lirong;CHEN Lin;HU Shuo;GAO Shi;FU Li-ping;CUI Rui-xue;GE Jing-jie;GUAN Yi-hui;ZUOChuan-tao;WANG Jian(Department of Neurology,Huashan Hospital,Fudan University,National Center for Neurological Disorders,National Clinical Research Center for Aging and Medicine,Shanghai 200040,China;Department of Nuclear Medicine&PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China;Department of Neurology,Union Hospital,Beijing 100730,China;Department of Nuclear Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China;Department of Nuclear Medicine,the Affiliated Hospital of Qingdao University,Qingdao 266071,China;Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Radiology&Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Nuclear Medicine,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Nuclear Medicine&Minnan PET Center,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China;Department of Neurology,General Hospital of Tianjin Medical University,Tianjin 300052,China;Department of Nuclear Medicine,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Neurology,the First Affiliated Hospital of Sun Yatsen University,Guangzhou 510080,China;Department of PET Center,Xiangya Hospital,Central South University,Changsha 410008,China;China-Japan Union Hospital,Jilin University,Changchun 130033,China;Department of Nuclear Medicine,China-Japan Friendship Hospital,Beijing 100029,China;Department of Nuclear Medicine,Union Hospital,Beijing 100730,China)
出处
《中国临床神经科学》
2022年第6期601-609,共9页
Chinese Journal of Clinical Neurosciences
基金
国家卫生健康委员会国家临床重点专科建设项目(编号:Pro20211231084249000238)
上海市“脑与类脑智能”市级重大科技专项资助(编号:2018SHZDZX01)和张江实验室,上海脑学科与类脑研究中心资助
上海市卫生健康委老龄化和妇儿健康研究专项(编号:2020YJZX0111)
上海申康医院发展中心临床三年行动计划资助(编号:SHDC2020CR1038B)
国家自然科学基金项目(编号:82171252、82021002、81701250)
中央高水平医费临床研究业务费资助(编号:2022-PUMCH-B-070)。
