血清淀粉样蛋白A与糖尿病合并认知损害的相关性研究进展

Research Progress on the Relationship between Diabetes with Cognitive Dysfunction and Serum Amyloid A

认知损害与糖尿病密切相关,2型糖尿病作为一种慢性炎性代谢性疾病被认为是导致认知损害的独立危险因素。血清淀粉样蛋白A作为炎性因子被发现在患有认知损害患者的血清中明显升高,且参与了糖尿病合并认知损害的发病机制中。因此认识并加强关于糖尿病认知损害与血清淀粉样蛋白A的相关性研究,将对提高糖尿病合并认知损害患者的生活质量具有重要意义。文中综述血清淀粉样蛋白A的生物学特性及功能、糖尿病伴认知损害的血清淀粉样蛋白A的病理学特点、发病机制等研究进展。

Diabetes is closely related to cognitive impairment.As a chronic inflammatory metabolic disease,type 2 diabetes is considered to be an independent risk factor for cognitive impairment.In recent years,serum amyloid A,as an inflammatory factor,has been found to be significantly increased in patients with cognitive dysfunction and has been involved in many pathogenesis of diabetes with cognitive dysfunction.Therefore,it is of great significance to understand and strengthen the research on serum amyloid A in diabetics with cognitive dysfunction,so as to improve the quality of life of patients with diabetes and cognitive dysfunction.The biological characteristics and functions of serum amyloid A,the pathological characteristics and pathogenesis of serum amyloid A with diabetes and cognitive impairment were reviewed.