1990年和2019年中国胰腺癌疾病负担及危险因素研究

Disease burden and risk factors of pancreatic cancer in China in 1990 and 2019

目的 分析1990年和2019年中国胰腺癌发病、死亡和疾病负担情况。方法 利用2019年全球疾病负担数据库,分析总人群、不同年龄组间1990年和2019年我国胰腺癌发病、死亡、伤残调整寿命年(DALY)、过早死亡损失寿命年(YLL)和伤残损失寿命年(YLD),并对胰腺癌进行危险因素归因分析。结果 2019年中国胰腺癌发病人数为11.49万,发病率为8.08/10万,较1990年分别增长了330.34%和257.52%。2019年死亡人数为11.74万,死亡率为8.25/10万,较1990年分别上升了333.21%和260.26%。2019年中国胰腺癌DALY、YLD和YLL分别为280.52万人年、2.39万人年和278.13万人年,较1990年分别上升了274.33%、319.30%和273.98%。2019年胰腺癌发病率、死亡率和DALY率均随年龄增长而升高,发病率、死亡率和DALY率最高的年龄组均为>70岁年龄组,分别为44.75/10万、50.09/10万和742.81/10万。中国胰腺癌归因于吸烟导致的死亡人数、DALY和YLL分别为26 552人年、612 359人年和607 033人年。结论 我国胰腺癌的疾病负担在1990-2019年间有较大增长,应采取积极的预防措施以减轻胰腺癌的疾病负担。

Objective To analyse the incidence, mortality and disease burden of pancreatic cancer in China in 1990 and 2019. Methods The global disease burden database in 2019 was used to analyse the incidence, mortality, disability adjusted life years(DALY), premature death loss years(YLL) and disability life years(YLD) of pancreatic cancer in the total population and age groups in 1990 and 2019. Risk factors attributable to pancreatic cancer were also analysed. Results The incidence of pancreatic cancer in China was 114 900 in 2019, and the incidence rate was 8.08/10~5, representing an increase of 330.34% and 257.52% compared with 1990. In 2019, the number of deaths was 117 400, and the mortality rate was 8.25/10~5, indicating an increase of 333.21% and 260.26% compared with 1990. In 2019, the DALY, YLD and YLL of pancreatic cancer in China were 2 805 200, 23 900 and 2 781 300, by contrast, form 1990, such values increased by 274.33%, 319.30% and 273.98%, respectively. In 2019, the incidence rate, mortality rate and DALY rate of pancreatic cancer increased with age. The highest incidence rate(44.75/10~5), mortality rate(50.09/10~5) and DALY rate(742.81/10~5) were all observed in the >70 age group. The mortality rate, DALY and YLL attributed to smoking in Chinese patients with pancreatic cancer was 26 552, 612 359 and 607 033, respectively. Conclusion The burden of pancreatic cancer in China has increased considerably from 1990 to 2019. Therefore, positive preventive measures should be taken to reduce the burden of pancreatic cancer.