胸腹腔镜食管切除术治疗食管癌的临床效果及对患者术后恢复、免疫功能的影响

Clinical effect of thoracic laparoscopic esophagectomy in the treatment of esophageal cancer and its influences on postoperative recovery and immune function of patients

目的分析胸腹腔镜食管切除术在食管癌患者中的应用效果。方法选取2016年1月至2020年12月我院收治的70例食管癌患者作为研究对象,根据手术治疗方案不同将其分为对照组(20例,开胸食管切除术)和试验组(50例,胸腹腔镜食管切除术)。比较两组的手术效果。结果术后3 d,试验组的心房利钠肽(ANP)、丙二醛(MDA)水平低于对照组,谷胱甘肽过氧化物酶(GSH-Px)水平高于对照组(P<0.05)。试验组的术后下床时间、引流时间、住院时间短于对照组,术后第3天视觉模拟量表(VAS)评分低于对照组(P<0.05)。术后第7天,试验组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原8阳性(CD8^(+))、CD4^(+)/CD8^(+)优于对照组(P<0.05)。结论胸腹腔镜食管切除术治疗食管癌的效果显著,有利于促进患者术后快速恢复,值得推广。

Objective To analyze the application effect of thoracic laparoscopic esophagectomy in patients with esophageal cancer.Methods A total of 70 patients with esophageal cancer admitted in our hospital from January 2016 to December 2020 were selected as the research objects.According to different surgical treatment schemes,the patients were divided into control group(20 cases,thoracotomy esophagectomy)and experimental group(50 cases,thoracic laparoscopic esophagectomy).The surgical effects of the two groups were compared.Results At 3 d after operation,the levels of atrial natriuretic peptide(ANP)and malondialdehyde(MDA)in the experimental group were lower than those in the control group,and the level of glutathione peroxidase(GSH-Px)was higher than that in the control group(P<0.05).The time of getting out of bed,drainage time and hospital stay in the experimental group were shorter than those in the control group,and the Visual Analog Scale(VAS)score on the third day after operation was lower than that in the control group(P<0.05).On the 7th day after operation,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+)),cluster of differentiation 8 positive(CD8^(+))and CD4^(+)/CD8^(+)in the experimental group were better than those in the control group(P<0.05).Conclusion Thoracic laparoscopic esophagectomy in the treatment of esophageal cancer is effective,it is beneficial to promote the rapid recovery of patients after operation,which is worthy of promotion.