促性腺激素释放激素拮抗剂方案黄体支持加用戊酸雌二醇对活产率和早产率的影响

Effect of Luteal Support with Estradiol Valerate on Live Birth Rate and Preterm Birth Rate in Patients Undergoing Gonadotropin Releasing Hormone Antagonist Protocols

目的分析黄体支持中加用戊酸雌二醇(EV)对接受促性腺激素释放激素拮抗剂(GnRH-ant)方案促排卵的新鲜胚胎移植患者活产率和早产率的影响。方法回顾性分析2018年6月至2019年12月于医院接受前述治疗患者的临床资料,根据黄体支持是否加用EV,分为对照组(黄体酮注射液,PI;148例)和观察组(PI+EV,333例),采用单因素和多因素Logistic回归分析。结果纳入481例患者,观察组和对照组的活产率分别为36.94%和36.49%,早产率分别为10.57%和9.26%。单因素分析结果显示,各纳入自变量均非活产率、早产率的显著性影响因素(P>0.05);多因素Logistic回归分析结果显示,加用EV不是活产率[OR=1.02,95%CI(0.68,1.52)]或早产率[OR=1.17,95%CI(0.39,3.47)]的独立影响因素(P>0.05)。结论GnRH-ant方案中黄体支持加用EV不影响活产率和早产率。

Objective To analyze the effect of luteal support with estradiol valerate(EV)on live and preterm birth in patients undergoing gonadotropin releasing hormone antagonist(GnRH-ant)protocols for fresh embryo transplantation.Methods The clinical data of the patients who received the aforementioned treatment in the hospital from June 2018 to December 2019 were retrospectively analyzed.According to whether EV was added to the luteal support,they were divided into the control group(Progesterone Injection,PI;148 cases)and the observation group(PI+EV,333 cases).Univariate and multivariate Logistic regression were used for the analysis.Results A total of 481 patients were included.In the observation group and the control group,the live birth rates were 36.94% and 36.49%,and the preterm birth rates were 10.57% and 9.26%.The results of univariate analysis showed that none of the included independent variables were the influencing factors of live birth rate and preterm birth rate(P>0.05).The results of multivariate Logistic regression analysis showed that the addition of EV was not an independent influencing factor of live birth rate[OR=1.02,95%CI(0.68,1.52)]or preterm birth rate[OR=1.17,95%CI(0.39,3.47)](P>0.05).Conclusion The luteal support with EV in GnRH-ant protocol does not affect the live birth rate and preterm birth rate.