肿瘤微环境中的基质细胞在肺癌发生发展中的作用机制

The mechanism of stromal cells in tumor microenvironment in the development and progression of lung cancer

肺癌因其高发生率和高致死率引起众多研究者的关注。肿瘤微环境在肺癌的发生发展中发挥重要作用。肿瘤微环境由肿瘤细胞、周围血管、细胞外基质、信号分子以及其他基质细胞组成,其中,基质细胞对肺癌的作用尚未完全明确。因此,本文就肿瘤微环境中的基质细胞对于肺癌的进展、肺癌治疗耐药性的影响及其相关作用机制等研究展开综述,以期为肺癌的早期诊断和改善预后提供新的思路。

Due to its high incidence and lethallty rate,lung cancer has attracted researchers’attention worldwide.Tumor microenvironment has been considered to play a critical role in the development of lung cancer.To our knowledge,tumor microenvironment consists of tumor cells,surrounding blood vessels,as well as the extracellular matrix,signaling molecules and some other stromal cells.However,the specific role of stromal cells in the development of lung cancer has not been uncovered thoroughly.In this paper,the role of stromal cells in the tumor microenvironment involved in the development and drug resistance in lung cancer and their active mechanism and even some other related research progress are reviewed,so as to facilitate innovation for the early diagnosis of lung cancer and improvement of the prognosis.