摘要
脊椎动物胚胎发育阶段,脊髓的形成是神经系统发育早期阶段,伴随原始神经组织尾部的退化发育而成.脊髓的发育伴随着原始神经组织的发育延长,包括神经发生和神经嵴发育等,被成纤维细胞生长因子(Fibroblast Growth Factor,FGF)信号通路严格调控.本文综述了脊髓发育过程中FGF信号通路的作用,以及与其它信号通路相互作用对脊髓发育的影响.FGF信号通路促脊髓发育作用显示其在脊髓损伤中促进再生的可能性和被用于临床治疗的前景.
Spinal cord is formed in the early stage of neural system development with caudal regression of the primitive streak during vertebrate embryonic development.Caudal extension related to spinal cord development including neurogenesis and neural crest development which strictly regulated by Fibroblast Growth Factor(FGF).This review explained the role of FGF signaling in spinal cord development and FGF different functions and interactions with other signaling pathways.The role of FGF signaling in spinal cord development shows the probability of regeneration in the lesioned spinal cord and application prospects in therapeutical.
作者
黎婷
刘宽辉
谢诗慧
刘少华
LI Ting;LIU Kuanhui;XIE Shihui;LIU Shaohua(School of Food and Bioengineering,Wuhu Institue of Technology/Life and Health Engineering Research Center of Wuhu,Wuhu,Anhui 241000;Detection of Food-borne Pathogenic Microorganisms Engineering Research Center of Wuhu,Wuhu,Anhui 241000)
出处
《绵阳师范学院学报》
2023年第2期68-73,共6页
Journal of Mianyang Teachers＇ College
基金
安徽省自然科学研究重点项目(KJ2021A1336)
安徽省高校优秀拔尖人才培育项目--高校优秀青年骨干人才国内外访学研修项目(gxgwfx2019072)
芜湖职业技术学院校级人才项目(wzyrc201801)
安徽省质量工程项目动物防疫与检疫教学团队(2020jxtd282)。
关键词
FGF
脊髓
发育
FGF
spinal cord
development
