硫酸镁联合硝苯地平在妊高症中的应用效果及安全性探讨

Exploring the Effect and Safety of Magnesium Sulfate Combined with Nife⁃dipine in Hyperemesis Gravidarum

目的探讨在妊高症患者中采取硫酸镁与硝苯地平联合治疗的效果以及安全性。方法回顾性选取2019年10月—2021年10月在淄博市妇幼保健院治疗的100例妊高症患者作为研究对象,按照治疗方式分为研究组与参照组,各50例。参照组单纯选择硫酸镁进行治疗,研究组在参照组的基础上加用硝苯地平片进行治疗。比较两组患者的治疗效果、不良反应发生情况、治疗前后的临床指标及分娩结局。结果研究组的治疗总有效率为94.00%,高于参照组的74.00%,差异有统计学意义(χ^(2)=7.440,P<0.05)。研究组的不良反应发生率为6.00%,低于参照组的20.00%,差异有统计学意义(P<0.05)。治疗前两组患者的各项临床指标比较,差异无统计学意义(P>0.05);治疗后,两组24 h尿蛋白、血液黏度、舒张压及收缩压均低于治疗前,且研究组上述指标低于参照组,差异有统计学意义(P<0.05)。研究组患者的剖宫产、早产、产后出血、新生儿窒息及胎儿窘迫发生率分别为8.00%、6.00%、2.00%、2.00%、4.00%,低于参照组的32.00%、20.00%、16.00%、16.00%、22.00%,差异有统计学意义(P<0.05)。结论采取硫酸镁与硝苯地平对妊高症患者进行联合治疗,能够有效提高治疗效果,显著改善分娩结局、24 h尿蛋白、血液黏度、舒张压及收缩压,降低不良反应发生的情况,安全性更高。

Objective To explore the effect and safety of combining magnesium sulfate with nifedipine in patients with hyperemesis gravidarum.Methods One hundred cases of hypertension patients treated in Zibo Maternal and Child Health Hospital from October 2019 to October 2021 were retrospectively selected as the study subjects,and were di⁃vided into study group and reference group according to the treatment modality,with 50 cases each.The reference group was treated with magnesium sulfate alone,and the study group was treated with nifedipine tablets on the basis of the reference group.The treatment effect,the occurrence of adverse reactions,the clinical indexes before and after treatment and the delivery outcome of the two groups were compared.Results The total effective rate of treatment in the study group was 94.00%,which was higher than that in the reference group of 74.00%,and the difference was sta⁃tistically significant(χ^(2)=7.440,P<0.05).The incidence of adverse reactions in the study group was 6.00%,which was lower than that in the reference group of 20.00%,and the difference was statistically significant(P<0.05).The differ⁃ences of the clinical indexes between the two groups before treatment were not statistically significant (P>0.05). Aftertreatment, 24-h urine protein, blood viscosity, diastolic blood pressure and systolic blood pressure in both groups werelower than those before treatment, and the above indexes in the study group were lower than those in the referencegroup, the difference was statistically significant (P<0.05). The incidence of cesarean delivery, preterm delivery, post⁃partum hemorrhage, neonatal asphyxia and fetal distress in the study group was 8.00%, 6.00%, 2.00%, 2.00% and4.00%, respectively, which were lower than those in the reference group of 32.00%, 20.00%, 16.00%, 16.00% and22.00%, and the difference was statistically significant (P<0.05).Conclusion Combined treatment of patients with hy⁃peremesis with magnesium sulfate and nifedipine can effectively improve the therapeutic effect, significantly improvelabor outcome, 24-h urine protein, blood viscosity, diastolic blood pressure and systolic blood pressure, and reducethe occurrence of adverse effects with higher safety.