靶向溃疡性结肠炎相关通路的药物研究进展

Research progress on drugs targeting ulcerative colitis-related pathways

溃疡性结肠炎(UC)是一种慢性的、病因未明的炎症性肠道疾病,目前的治疗药物以氨基水杨酸类、糖皮质激素类非特异性药物为主。通过靶向UC相关的信号通路来寻找靶向药物治疗UC,发展特异性的治疗措施是该病药物研发的必然要求。该文综合阐述了与UC相关的信号通路在发病机制中的作用及相关靶向药物的研究进展,以期为UC疾病的治疗提供完善的依据。

Ulcerative colitis(UC) is a chronic inflammatory intestinal disease with unknown etiology.At present, the main therapeutic drugs are aminosalicylic acid and glucocoticoids.It is an inevitable requirement for drug research and development to find targeted drugs to treat UC specifically through UC-related signal pathways.This paper comprehensively expounded the role of UC-related signaling pathways on the pathogenesis and the research progress of drugs targeting specific pathways in order to provide a sound basis for the treatment of UC.