小剂量米非司酮治疗更年期功能性子宫出血的临床疗效分析

Clinical analysis of low dose Mifepristone in the treatment of menopausal functional uterine bleeding

目的分析针对更年期功能性子宫出血患者采取小剂量米非司酮治疗的临床疗效。方法选取100例更年期功能性子宫出血患者,根据治疗方式不同将患者分为米酮组与黄酮组,每组50例。米酮组患者采取小剂量米非司酮治疗,黄酮组患者采取黄体酮治疗。比较两组临床疗效。结果米酮组治疗总有效率96.00%明显高于黄酮组的82.00%,差异有统计学意义(P<0.05)。米酮组雌二醇(E_(2))、卵泡刺激素(FSH)及促黄体生成素(LH)水平均明显低于黄酮组,差异有统计学意义(P<0.05)。米酮组不良反应发生率显著低于黄酮组,差异有统计学意义(P<0.05)。结论小剂量米非司酮治疗更年期功能性子宫出血的效果确切,可改善患者性激素水平,且安全性较高,值得临床推广与应用。

Objective To analyze the clinical effect of low dose mifepristone therapy on menopausal patients with functional uterine bleeding.Methods 100 patients with menopausal functional uterine bleeding were selected and divided into midone group and flavonoid group according to different treatment methods,with 50 cases in each group.Patients in the midone group were treated with low-dose mifepristone,while those in the flavonoid group were treated with progesterone.The clinical efficacy of the two groups was compared.Results The total eflfective rate of the midone group was 96.00%,which was significantly higher than that of the flavonoid group 82.00%,and the difference was statistically significant(P<0.05).The levels of estradiol(E_(2)),follicle stimulating hormone(FSH)and luteinizing hormone(LH)in midone group were significantly lower than those in flavonol group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in midone group was significantly lower than that in flavonoid group,and the difference was statistically significant(P<0.05).Conclusion Low-dose mifepristone is effective in the treatment of menopausal functional uterine bleeding,and can improve the level of sex hormones in patients with high safety,which is worthy of clinical promotion and application.