寻常型银屑病患者焦虑与病情、氧化应激及炎症因子的相关性研究

Correlation analysis of anxiety with psoriasis severity, oxidative stress and inflammatory factors in patients with psoriasis vulgaris

目的:探究寻常型银屑病患者焦虑状况,分析银屑病患者焦虑与病情、氧化应激及炎症因子的相关性。方法:招募2021年8月~2022年2月东直门中医院皮肤科的84例银屑病患者,采集汉密尔顿焦虑量表评分(HAMA)、银屑病皮损面积和严重程度指数评分(PASI)、VAS瘙痒评分(VAS),检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、白介素-6(IL-6)、白介素-17A(IL-17A)、肿瘤坏死因子-α(TNF-α)。基于HAMA评分进行分组对照研究及相关性分析,此外采集84例健康人的HAMA评分进行对照研究。结果:寻常型银屑病患者HAMA评分高于健康人(Z=-7.730,P<0.05);寻常型银屑病伴焦虑患者在PASI、VAS评分,MDA、SOD、GSH-px、IL-6、IL-17A分泌水平均与寻常型银屑病无焦虑患者存在差异;寻常型银屑病患者HAMA评分与PASI、VAS评分呈显著正相关(r=0.564,0.513,P<0.05);与血清中MDA、IL-6、IL-17A呈正相关性(r=0.390,0.355,0.248,P<0.05);与SOD、GSH-px呈负相关(r=-0.313,-0.502,P<0.05);未发现与TNF-α的相关性。结论:银屑病患者焦虑风险高于健康人群;焦虑与银屑病关系密切,并体现在银屑病患者的皮损、瘙痒、氧化应激及炎症因子水平等方面;焦虑与银屑病共病机制可能与氧化应激亢进、炎症因子水平上调相关。

Objective: To investigate the anxiety status of patients with psoriasis vulgaris, and analyze the correlation between anxiety and severity of the disease, oxidative stress factors and inflammatory factors.Methods: From August 2021 to February 2022, 84 patients with psoriasis in the dermatology department of Dongzhimen Hospital of Traditional Chinese Medicine were recruited. Hamilton Anxiety Scale(HAMA), Psoriasis Lesion Area and Severity Index(PASI), VAS Pruritus Scale(VAS) were collected to detect serum malondialdehyde(MDA), superoxide dismutase(SOD), glutathione peroxidase(GSH px), interleukin-6(IL-6), interleukin-17A(IL-17A), and tumor necrosis factor-α(TNF-α).Based on the HAMA score, a group controlled study and correlation analysis were conducted. In addition, the HAMA scores of 84 healthy people were collected for a controlled study.Results: HAMA score of patients with psoriasis vulgaris was higher than that of healthy people(Z=-7.730, P<0.05);There were differences in PASI, VAS scores, MDA, SOD, GSH px, IL-6, IL-17A secretion levels between psoriasis vulgaris patients with anxiety and psoriasis vulgaris patients without anxiety;HAMA score was positively correlated with PASI and VAS scores in patients with psoriasis vulgaris(r=0.564, 0.513, P<0.05);It was positively correlated with MDA, IL-6, IL-17A in serum(r=0.390, 0.355, 0.248, P<0.05);It was negatively correlated with SOD and GSH px(r=-0.313,-0.502, P<0.05);and TNF-αnot relevant.Conclusion: The anxiety risk of psoriasis patients was higher than that of healthy people;Anxiety is closely related to psoriasis, and is reflected in the skin lesions, itching, oxidative stress and inflammatory factor levels of psoriasis patients;The comorbidity mechanism of anxiety and psoriasis may be related to oxidative stress and up regulation of inflammatory factors.