免疫检查点抑制剂导致免疫相关不良反应的研究进展

Research progress of immune-related adverse reactions caused by immune checkpoint inhibitors

癌症是中国人群的主要死亡原因之一,近年来,随着人们对癌症研究的深入,免疫检查点抑制剂(ICIs)成为继手术治疗、化学治疗、放射治疗后的新治疗方法,使癌症患者的预后明显改善。但随着免疫治疗临床数据的反馈,免疫治疗的不良反应也逐渐显露出来,因此在注重治疗的同时也应重视其不良反应。本文主要论述了免疫检查点抑制剂治疗肿瘤及其不良反应方面的研究现状及进展,以期对广大临床工作者开展工作有所帮助。

Cancer is one of the major causes for death in China. In recent years, with the in-depth research on cancer, immune checkpoint inhibitors(ICIs) have entered the limelight and become a new treatment method after surgery, chemotherapy and radiotherapy, resulting in a significantly improved prognosis for cancer patients. However, with the feedback of clinical data of immunotherapy, its adverse effects are also gradually exposed, therefore, attention should also be paid to them while focusing on the treatment with the new method. This paper mainly reviews the research status and progress of immune checkpoint inhibitors in the treatment of tumors and their adverse reactions, with the aim of providing a help to doctors in their work.