布洛芬混悬液与对乙酰氨基酚片治疗脊髓损伤合并泌尿系统感染发热患者的临床疗效分析

Clinical Efficacy Analysis of Ibuprofen Suspension and Acetaminophen Tablets in the Treatment of Spinal Cord Injury Patients Complicated with Urinary System Infection and Fever

目的观察布洛芬混悬液与对乙酰氨基酚片在脊髓损伤合并泌尿系统感染发热患者中的治疗效果,旨在提高患者整体获益水平。方法纳入本院2020年1月-2022年2月收治的70例脊髓损伤合并泌尿系统感染发热患者为研究对象,按随机数表法分为对照组(35例,对乙酰氨基酚片)与观察组(35例,布洛芬混悬液),对比两组治疗效果、不同时点体温变化情况及不良反应发生情况。结果观察组整体治疗效果优于对照组,差异有统计学意义(Z=2.564,P=0.010),两组治疗总有效率对比,差异无统计学意义(χ^(2)=1.393,P=0.238);给药前,两组患者腋下体温对比,差异无统计学意义(t=1.775,P=0.080),给药后,两组患者腋温均下降,且与对照组相比,观察组给药后30min(38.02±0.50)℃、给药后60min(37.11±0.32)℃、给药后2h(36.56±0.34)℃腋温均较低,差异均有统计学意义(t=4.679、9.643、13.830,P<0.001),两组患者给药后4h腋温对比,差异无统计学意义(t=1.166,P=0.248);两组不良反应总发生率对比[观察组低于对照组,差异无统计学意义(t=0.265,P=0.607)。结论脊髓损伤合并泌尿系统感染发热患者采用布洛芬混悬液,退热效果优于对乙酰氨基酚片,且安全性理想,可在临床推荐使用。

Objective To observe the therapeutic effect of ibuprofen suspension and acetaminophen tablets in patients with spinal cord injury complicated with urinary system infection and fever,aiming to improve the overall benefit level of patients.Methods 70 spinal cord patients with urinary system infection and fever treated in our hospital from January 2020 to February 2022 were included as the research objects.They were randomly divided into control group(35 cases,acetaminophen tablets)and observation group(35 cases,ibuprofen suspension).The therapeutic effects,temperature changes and adverse reactions of the two groups were compared.Results The overall treatment effect of the observation group was better than that of the control group,and the difference was statistically significant(Z=2.564,P=0.010).There was no significant difference in the total effective rate between the two groups(χ^(2)=1.393,P=0.238);Before administration,there was no significant difference in axillary temperature between the two groups(t=1.775,P=0.080).After administration,the axillary temperature of the two groups decreased.Compared with the control group,the axillary temperature of the observation group was lower at 30min(38.02±0.50)℃,60min(37.11±0.32)℃and 2h(36.56±0.34)℃after administration(t=4.679,9.643,13.830,P<0.001).There was no significant difference in axillary temperature between the two groups 4 hours after administration(t=1.166,P=0.248).There was no significant difference in the total incidence of adverse reactions between the two groups(t=0.265,P=0.607).Conclusion The antipyretic effect of ibuprofen suspension in patients with spinal cord injury combined with urinary system infection fever is better than that of paracetamol tablets,and the safety is satisfactory.It can be recommended in clinical practice.