腹腔镜联合胆道镜治疗胆石症并发胰腺炎患者的氧化应激反应及预后情况分析

Analysis of Oxidative Stress Response and Prognosis in Patients withCholelithiasis Complicated with Pancreatitis Treated by LaparoscopyCombined with Choledochoscopy

目的:分析胆石症并发胰腺炎患者实行腹腔镜联合胆道镜治疗的氧化应激反应及预后情况。方法:选取我院2020年1月—2022年8月收治的胆石症并发胰腺炎患者66例作为研究对象,按数字表法将其随机分为对照组(n=33)和研究组(n=33)。开腹手术治疗纳入对照组,腹腔镜联合胆道镜治疗纳入研究组,比对两组围手术期指标、氧化应激反应指标及并发症发生率。结果:研究组较对照组明显降低术中出血量、血清丙二醛(MDA)、氧化型低密度脂蛋白(ox-LDL)水平及并发症发生率,升高血清氧磷酶-1(PON-1)水平,缩短胃肠道通气时间、术后住院时间及手术时间,组间差异明显(P<0.05)。结论:胆石症并发胰腺炎病患以腹腔镜联合胆道镜采取治疗,有利于降低病患出血量,稳定生命体征,改善应激指标,实践价值较高。

Objective:To analyze the oxidative stress response and prognosis of cholelithiasis complicated with pancreatitis treated by laparoscopy combined with choledochoscopy.Methods:66 patients with cholelithiasis complicated with pancreatitis admitted to our hospital from January 2020 to August 2022 were selected as the research objects,and randomly divided into control group(n=33)and study group(n=33)according to the number table method.Open surgery was included in the control group,and laparoscopy combined with choledochoscopy was included in the study group.Perioperative indicators,oxidative stress response indicators and incidence of complications were compared between the two groups.Results:Compared with the control group,the study group significantly reduced the intraoperative blood loss,serum malondialdehyde(MDA),oxidized low-density lipoprotein(ox-LDL)levels and the incidence of complications,increased the serum oxonase-1(PON-1)level,and shortened the gastrointestinal ventilation time,postoperative hospital stay and operation time,with significant differences between the groups(P<0.05).Conclusion:Laparoscopy combined with choledochoscopy in the treatment of cholelithiasis complicated with pancreatitis is beneficial to reduce the amount of blood loss,stabilize the vital signs,improve the stress index,and has high practical value.