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植物甾醇α-亚麻酸酯的制备及在负载虾青素脂质体中的应用 被引量:2

Preparation of phytosterolα-linolenic acid ester and its application in astaxanthin-loaded liposomes
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摘要 目的:提高虾青素的水溶性、稳定性。方法:以植物甾醇和α-亚麻酸为原料制备植物甾醇α-亚麻酸酯;以大豆磷脂为膜材,采用薄膜—超声法构建虾青素—植物甾醇α-亚麻酸酯复合脂质体。结果:红外光谱法和核磁共振法结构分析表明产物为植物甾醇α-亚麻酸酯,气相色谱测定其纯度为(90.72±2.09)%;虾青素—植物甾醇α-亚麻酸酯复合脂质体的包封率为(95.00±0.66)%,平均粒径为(158.70±9.70)nm,多相分散系数(PDI)为0.35±0.02,zeta电位为(-33.87±2.48)mV。透射电子显微镜观察到复合脂质体囊泡近似球形、形状规则、分散性好。结论:植物甾醇α-亚麻酸酯可用于制备负载虾青素的脂质体。 Objective:This study focuses on improving the stability and water solubility of astaxanthin.Methods:Phytosterolα-linolenic acid ester was synthesized by chemical method with phytosterol andα-linolenic acid as raw materials.Liposomes co-encapsulating astaxanthin and phytosterolα-linolenic acid ester were prepared by employing a thin-film ultrasound technique with the utilization of soybean phospholipid.Results:Based on the structure analysis by infrared spectroscopy and nuclear magnetic resonance,it has been demonstrated that the product was phytosterolα-linolenic acid ester.The purity of phytosterolα-linolenic acid ester was(90.72±2.09)%by gas chromatography.The encapsulation efficiency of liposomes co-encapsulating astaxanthin and phytosterolα-linolenic acid ester were(95.00±0.66)%,the average particle size was(158.70±9.70)nm,the polydispersity index(PDI)was 0.35±0.02,and the average zeta potential was(-33.87±2.48)mV.Transmission electron microscopy revealed that the complex liposomes were spherical with regular shape and uniform particle size distribution.Conclusion:Phytosterolα-linolenic acid ester could be applied in the preparation of astaxanthin-loaded liposomes.
作者 刘彦君 潘丽 常振刚 孟豪杰 张国治 LIU Yan-jun;PAN Li;CHANG Zhen-gang;MENG Hao-jie;ZHANG Guo-zhi(College of Food Science and Engineering,Henan University of Technology,Zhengzhou,Henan 450001,China;Henan Jingu Industry Development Co.,Ltd.,Zhengzhou,Henan 450003,China)
出处 《食品与机械》 北大核心 2022年第12期133-138,144,共7页 Food and Machinery
基金 国家自然科学基金青年科学基金项目(编号:32001738) 郑州市科技局自然科学项目(编号:21ZZXTCX18) 河南工业大学青年骨干教师培育计划项目(编号:20201101)。
关键词 植物甾醇 Α-亚麻酸 植物甾醇α-亚麻酸酯 虾青素 复合脂质体 phytosterol α-linolenic acid phytosterol α-linolenic acid ester astaxanthin complex liposomes
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