摘要
干扰素基因刺激蛋白(Stimulator of interferon genes,STING)的发现是天然免疫研究领域的一个重要里程碑,其能够识别在细菌生命中发挥重要作用的环状二核苷酸(CDNs),包括c-di-GMP和c-di-AMP,也能识别宿主细胞质DNA感受器cGAS合成的2′3′-cGAMP。CDNs与STING的结合使TBK1-IRF3信号通路被激活,并最终诱导Ⅰ型干扰素(IFN-Ⅰ)的产生。鉴于STING在天然免疫反应中的核心地位,STING信号通路在宿主对抗多种细菌感染过程中的作用逐渐被揭示。论文系统阐述了STING介导的天然免疫信号激活及其在宿主抗细菌感染中的重要功能,同时总结了细菌通过抑制STING信号通路激活进行免疫逃逸的相关研究进展。
The characterization of STING is a milestone in the innate immunity research field.It can recognize cyclic dinucleotides(CDNs),including c-di-GMP and c-di-AMP that play an important role in bacterial life,and it can also recognize 2′3′-cGAMP synthesized by the host cytoplasmic DNA sensor cGAS.The binding of CDNs to STING activates the TBK1-IRF3 signaling pathway and induces the production of type I interferon(IFN).Given the central role of STING in the innate immune response,the role of the STING signaling pathway in host defense against a variety of bacterial infections has been revealed.We systematically reviewed the induction of STING-mediated innate immune signaling and their role in host defense against bacterial infections,and also summarized the latest research progress of STING inhibition by bacteria to evade host immune surveillance.
作者
李梦园
王逍
沈锡辉
王瑶
徐磊
LI Meng-yuan;WANG Xiao;SHEN Xi-hui;WANG Yao;XU Lei(College of Life Science,Northwest A&F University,Yangling,Shaanxi,712100,China)
出处
《动物医学进展》
北大核心
2023年第2期84-88,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31800113,31725003),中国博士后科学基金特别资助项目(2020T130543),中国博士后科学基金面上资助项目(2018M631201)。
关键词
细菌
干扰素基因刺激蛋白
Ⅰ型干扰素
天然免疫
感染
bacteria
stimulator of interferon genes
typeⅠinterferon
innate immunity
infection