STING介导的天然免疫反应在细菌感染中作用研究进展

Progress on the Role of STING-mediated Innate Immunity in Bacterial Infections

干扰素基因刺激蛋白(Stimulator of interferon genes,STING)的发现是天然免疫研究领域的一个重要里程碑,其能够识别在细菌生命中发挥重要作用的环状二核苷酸(CDNs),包括c-di-GMP和c-di-AMP,也能识别宿主细胞质DNA感受器cGAS合成的2′3′-cGAMP。CDNs与STING的结合使TBK1-IRF3信号通路被激活,并最终诱导Ⅰ型干扰素(IFN-Ⅰ)的产生。鉴于STING在天然免疫反应中的核心地位,STING信号通路在宿主对抗多种细菌感染过程中的作用逐渐被揭示。论文系统阐述了STING介导的天然免疫信号激活及其在宿主抗细菌感染中的重要功能,同时总结了细菌通过抑制STING信号通路激活进行免疫逃逸的相关研究进展。

The characterization of STING is a milestone in the innate immunity research field.It can recognize cyclic dinucleotides(CDNs),including c-di-GMP and c-di-AMP that play an important role in bacterial life,and it can also recognize 2′3′-cGAMP synthesized by the host cytoplasmic DNA sensor cGAS.The binding of CDNs to STING activates the TBK1-IRF3 signaling pathway and induces the production of type I interferon(IFN).Given the central role of STING in the innate immune response,the role of the STING signaling pathway in host defense against a variety of bacterial infections has been revealed.We systematically reviewed the induction of STING-mediated innate immune signaling and their role in host defense against bacterial infections,and also summarized the latest research progress of STING inhibition by bacteria to evade host immune surveillance.