经典Wnt信号通路与子宫肌瘤

The canonical Wnt pathway and uterine leiomyoma

随着中国女性育龄期的延迟,健康查体和医学超声技术的进步,越来越多育龄期女性被发现患有子宫肌瘤。既往有症状的子宫肌瘤最主要的治疗方法是手术治疗,但子宫切除术和子宫肌瘤剔除术均会对育龄期女性生活质量产生不同程度的影响。因此,探讨子宫肌瘤发病机制,寻求新的治疗方法,对于罹患子宫肌瘤女性的诊治具有重要意义。经典Wnt信号通路是调节子宫肌瘤细胞增殖、凋亡的关键途径,参与子宫肌瘤的发生、发展。因此,探讨经典Wnt信号通路在子宫肌瘤中的作用机制对疾病的诊断、治疗和患者的预后具有重要的临床意义。

With the delay in the childbearing years of Chinese women and advances in health screening and medical ultrasound technology,more and more women of childbearing age are being found to have fibroids.Previously,the main treatment for symptomatic fibroids was surgery,but both hysterectomy and myomectomy can have varying degrees of impact on the quality of life of women of childbearing age.Therefore,it is important to investigate the pathogenesis of fibroids and to seek new treatment options for women with fibroids.The canonical Wnt pathway is a key pathway that regulates the proliferation and apoptosis of fibroid cells and is involved in the development of fibroids.Therefore,exploring the role of the canonical Wnt pathway in fibroids has important clinical implications for the diagnosis,treatment and prognosis of patients.