阿卡波糖联合二甲双胍治疗2型糖尿病的效果观察

Effect Observation of Acarbose Combined with Metformin in Treatment of Type 2 Diabetes Mellitus

目的:探讨阿卡波糖联合二甲双胍治疗2型糖尿病的效果。方法:选取2019年6月-2021年6月澧县人民医院收治的100例2型糖尿病患者作为研究对象,根据随机数字表法分成研究组和对照组,各50例。对照组给予二甲双胍治疗,研究组在对照组基础上给予阿卡波糖治疗。比较两组治疗效果、各项指标、颈动脉变化情况、患者满意度。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.0376)。治疗前,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平比较,差异无统计学意义(P>0.05);治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均优于治疗前,且研究组优于对照组,差异有统计学意义(P<0.05)。研究组颈动脉内膜厚度优于对照组,颈动脉斑块少于对照组,治疗后2年内脑卒中发生率低于对照组,差异有统计学意义(P<0.05)。研究组患者满意度高于对照组,差异有统计学意义(P<0.05)。结论:针对2型糖尿病患者的治疗,联合使用阿卡波糖及二甲双胍,可提升治疗效果。

Objective:To explore the effect of acarbose and metformin in the treatment of type 2 diabetes mellitus.Methods:A total of 100 patients with type 2 diabetes mellitus admitted to Lixian People’s Hospital between June 2019 and June 2021 were selected as the study subjects.They were divided into control group and study group according to random number table method,with 50 cases in each group.The control group was treated with metformin alone,and the study group was treated with acarbose on the basis of control group.The treatment effect,clinical testing indexes,change of carotid intima-media thickness and satisfaction were compared between two groups.Results:The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.0376).Before treatment,there was no significant difference in fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin indexes between the two groups(P>0.05).After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin indexes of the two groups were better than those before treatment,and the study group was better than the control group,and the difference was statistically significant(P<0.05).The carotid intima-media thickness in the study group was better than that in the control group,the number of carotid plaques was less than that in the control group,the incidence of stroke within 2 years after treatment was lower than that in the control group,and the difference was statistically significant(P<0.05).The overall satisfaction rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:In the treatment of patients with type 2 diabetes mellitus,the combined use of acarbose and metformin can improve the treatment effect.