中国公众对临床研究认知情况的调查与分析

Investigation and analysis of Chinese public’s cognition for clinical research

目的:临床研究对疾病研究和人群健康起着至关重要的作用,公众是临床研究志愿者的主要来源,了解公众对临床研究的认知程度对临床研究的开展和发展起着决定性作用。本研究拟了解中国公众对临床研究的认知情况和影响因素。方法:采用问卷星将公众对临床研究的了解和知晓程度(Public Awareness of Research for Therapeutic Advancements through Knowledge and Empowerment,PARTAKE)问卷中文翻译版本制作成网络问卷,在全国范围内对中国人群的临床研究认知程度进行在线调查。结果:在有效应答的2513人中,91.84%的被调查者知道“临床研究”,91.76%认为临床研究是对社会有益的,65.90%愿意参加临床研究,87.50%认为保密是一件非常重要的事情,73.70%认为参加临床研究时个人的信息得到了保护,但46.40%表示不知道参与临床研究的志愿者是否可以得到足够的补偿。不同文化程度、就业情况、年收入会导致中国民众对临床研究的认知出现差异,特别是在参加临床研究的意愿、隐私保护、知情同意、临床研究对社会是否有意义、临床研究的补偿和临床研究的安全性方面的认知差异有统计学意义(均P<0.01)。结论:中国公众对临床研究认知水平尚可,但在隐私保护、知情同意和获得补偿方面水平还有很大的提升空间;通过设计合理的临床研究知识培训方案、利用多媒体、改善临床研究相关知识普及等措施,让更多的公众获知临床研究招募信息并自愿参与到临床研究中,对中国的临床研究发展有着重要意义。

Objective:Clinical research plays a vital role in disease research and population health.The public is the main source of clinical research volunteers.Understanding the public’s cognition of clinical research plays a decisive role in the development of clinical research.This study aims to understand the Chinese public’s cognition for clinical research and the influencing factors.Methods:The questionnaire based on Chinese-translated Public Awareness of Research for Therapeutic Advancements through Knowledge and Empowerment(PARTAKE)was used to investigate the public’s cognition for clinical research.Results:Of the 2513 valid respondents,91.84%had heard of“clinical research”,91.76%of the respondents believed that clinical research was beneficial to society,65.90%were willing to participate in clinical research,87.50%believed that confidentiality was a very important thing,73.70%believed that their personal information had been protected when participating in clinical research,and,46.40%did not know whether volunteers participating in clinical research could receive adequate compensation.Educational levels,employment status,and annual income impacted in public perceptions of willingness to participate in clinical research,especially in privacy protection,informed consent,whether clinical research is intended for society,compensation for clinical research,and safety of clinical research(all P<0.01).Conclusion:The Chinese public’s cognition level for clinical research is acceptable,but there is still a lot of room for improvement in privacy protection,informed consent,and compensation.By designing a reasonable knowledge training program for clinical research and using the multimedia,improving access to the relevant knowledge,more public will know about clinical research recruitment information,which is of great significance for the development of clinical research in China.