肿瘤包绕型血管在肝细胞癌中的研究进展

Research progress of vessels encapsulating tumor clusters in hepatocellular carcinoma

早期转移是肝细胞癌(HCC)术后复发及病死率高的主要原因。目前,研究发现一种新的血管转移模式—肿瘤包绕型血管(VETC),不依赖经典的上皮-间质转化转移方式,其转移程度更高,预后更差,给HCC患者的精准治疗带来更大的挑战。故笔者总结VETC模式在HCC中研究现状、作用机制及临床意义,旨在为HCC的临床与基础研究提供参考。

Early metastasis is a significant cause of postoperative recurrence and high mortality of hepatocellular carcinoma(HCC). Vessels encapsulating tumor clusters(VETC), a unique vascular metastasis pattern independent of the traditional epithelial-mesenchymal transitions metastatic mode, has been discovered through recent studies. It is associated with a higher degree of metastasis and worse prognosis and poses a more significant challenge to the proper treatment for HCC patients. Herein, the authors summarize the research status, mechanism, and clinical significance of the VETC pattern in HCC, to serve as a reference for the clinical and basic research in HCC.