HPA轴在抑郁症中的研究概述

Research Overview of HPA Axis in Depression

抑郁症临床上的主要特点为显著而持久的心境低落,其高发病率和高致残性给个人、家庭及社会都带来了沉重的负担。近年来针对抑郁患者神经内分泌方面的研究表明,以下丘脑-垂体-肾上腺皮质轴(The hypothalamic–pituitary–adrenal axis,HPA axis)紊乱为主的失调在抑郁症的发病过程中起到了重要作用。综述近年来HPA轴与抑郁症的研究进展,以期为抑郁症的诊断与治疗提供新的思路及参考价值。

The main clinical feature of depression is marked and persistent low mood,and its high incidence and high disability have brought a heavy burden to individuals, families and society. Recent studies on neuroendocrine in patients with depression have shown that disorders of the hypothalamic-pituitary-adrenocortical axis(HPA axis) plays an important role in the pathogenesis of depression. This article reviews the research progress of HPA axis and depression in recent years,in order to provide new ideas and reference value for the diagnosis and treatment of depression.