温胆汤加味联合常规西药治疗痰浊型冠心病临床研究

Clinical Study on Modified Wendan Decoction Combined with Routine Western Medicine for Coronary Heart Disease of Turbid Phlegm Type

目的:观察温胆汤加味联合常规西药治疗痰浊型冠心病的临床疗效。方法:选取126例痰浊型冠心病患者为研究对象,随机分为对照组和研究组各63例。对照组给予常规西医治疗(阿司匹林+硝酸异山梨酯+辛伐他汀),研究组在对照组的基础上给予温胆汤加味治疗。比较2组临床疗效及不良反应情况,治疗前后血脂指标[甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]及血管内皮功能指标[一氧化氮(NO)、内皮素(ET)]水平变化。结果:研究组总有效率为96.8%,对照组为84.1%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清LDL-C、TG水平比较,差异无统计学意义(P>0.05);治疗后,2组LDL-C、TG水平均较治疗前降低(P<0.05),且研究组上述2项指标均低于对照组(P<0.05)。治疗前,2组血清NO、ET水平比较,差异无统计学意义(P>0.05)。治疗后,2组NO水平较治疗前升高(P<0.05),ET水平较治疗前降低(P<0.05);且研究组上述2项指标改善较对照组更显著(P<0.05)。治疗期间,研究组不良反应总发生率为3.2%,对照组为4.8%,2组比较,差异无统计学意义(P>0.05)。结论:温胆汤加味联合常规西药治疗痰浊型冠心病临床疗效显著,可明显改善患者的血脂水平及血管内皮功能,且用药安全性良好。

Objective:To observe the clinical effect of modified Wendan Decoction combined with routine western medicine for coronary heart disease of turbid phlegm type.Methods:A total of 126 cases of patients with coronary heart disease of turbid phlegm type were selected as the study subjects,and randomly divided into the control group and the study group,with 63 cases in each group.The control group was treated with routine western medicine(Aspirin,Isosorbide Mononitrate and Simvastatin),and the study group was additionally treated with modified Wendan Decoction based on the treatment of the control group.The changes in the levels of blood lipid including triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),and the indexes of vascular endothelial function including nitric oxide(NO)and endothelin(ET)before and after treatment,as well as the curative effects were compared between the two groups.Results:The total effective rate was 96.8% in the study group and 84.1%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of LDL-C and TG in serum between the two groups(P>0.05);after treatment,the levels of LDL-C and TG in the two groups were decreased when compared with those before treatment(P<0.05),and the above two indexes in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of NO and ET in serum between the two groups(P>0.05).After treatment,the NO levels in the two groups were increased when compared with those before treatment(P<0.05),and the ET levels were decreased(P<0.05);the improvement of the above two indexes in the study group was more significant than that in the control group(P<0.05).During treatment,the total incidence of adverse reactions was 3.2% in the study group and 4.8% in the control group,there being no significance in the difference(P>0.05).Conclusion:Modified Wendan Decoction combined with routine western medicine has a significant clinical effect in treating coronary heart disease of turbid phlegm type,which can obviously improve levels of blood lipid and vascular endothelial function in patients with good medication safety.