宣肃汤联合阿奇霉素治疗小儿肺炎临床研究

Clinical Study on Xuansu Decoction Combined with Azithromycin in Treating Pneumonia in Children

目的:观察宣肃汤联合阿奇霉素治疗小儿肺炎的临床疗效及对炎性因子水平的影响。方法:将106例肺炎患儿依据治疗方法不同分为对照组与观察组各53例,对照组采用阿奇霉素治疗,观察组在对照组基础上加用宣肃汤治疗。比较2组临床疗效及不良反应,比较2组治疗前后中医证候积分及C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)水平。结果:观察组治疗总有效率92.5%,高于对照组84.9%(P<0.05)。治疗前,2组发热、咳嗽、咳痰、哮鸣音等各项中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组发热、咳嗽、咳痰、哮鸣音等各项中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组CRP、TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);治疗后,2组CRP、TNF-α、IL-6水平均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:采用宣肃汤联合阿奇霉素治疗小儿肺炎效果较好,可以更快地缓解患儿症状,且不良反应发生率低,治疗安全性较高。

Objective:To observe the clinical effect of Xuansu Decoction combined with Azithromycin in treating pneumonia in children and its effects on the levels of inflammatory factors. Methods: A total of 106 cases of children with pneumonia were divided into the control group and the observation group according to different treatment methods,with 53 cases in each group. The control group was treated with azithromycin,and the observation group was treated with Xuansu Decoction combined with Azithromycin.Clinical effects and the incidence of adverse reactions were compared between the two groups. Traditional Chinese medicine(TCM) syndrome scores, and the levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6) in the two groups before and after treatment were compared.Results: The total effective rate was 92.5% in the observation group, higher than that of 84.9% in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of scores of fever,cough,expectoration and wheezing of TCM syndromes between the two groups(P>0.05). After treatment, scores of fever, cough, expectoration and wheezing of TCM syndromes in the two groups were decreased(P<0.05), and the scores in the observation group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of levels of CRP, TNF-α, and IL-6 between the two groups(P>0.05). After treatment,levels of CRP,TNF-α,and IL-6 in the two groups were decreased(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of Xuansu Decoction combined with Azithromycin has a good curative effect in treating pneumonia in children,which can relieve the symptoms of children more quickly,with low adverse reaction rates and high treatment safety.