穴位埋线疗法联合运中健脾汤治疗早发性卵巢功能不全临床研究

Clinical Study on Catgut Embedment in Point Combined with Yunzhong Jianpi Decoction for Premature Ovarian Insufficiency

目的:观察穴位埋线疗法联合运中健脾汤治疗早发性卵巢功能不全的临床疗效。方法:选取早发性卵巢功能不全患者80例,按随机数字表法分为中药组和联合组各40例。中药组给予运中健脾汤治疗,联合组在中药组基础上加用穴位埋线,均治疗12周。比较2组不同时间点中医证候评分、症状自评量表(SCL-90)评分,检测不同时间点血清激素水平,评价2组临床疗效。结果:联合组总有效率为87.5%,高于中药组70.0%,差异有统计学意义(P<0.05)。治疗4周、8周、12周后,2组主症及次症评分均较治疗前降低(P<0.05);且联合组主症、次症评分均低于同期中药组(P<0.05)。治疗4周、8周、12周后,2组SCL-90评分较治疗前降低(P<0.05);且联合组SCL-90评分低于同期中药组(P<0.05)。治疗4周、8周、12周后,2组促黄体生成激素(LH)、促卵泡生成激素(FSH)、孕酮(P)、睾酮(T)水平较治疗前降低,雌二醇(E_(2))、催乳素(PRL)水平较治疗前升高(P<0.05);且联合组LH、FSH、P低于同期中药组,E_(2)高于同期中药组(P<0.05)。结论:穴位埋线疗法联合运中健脾汤治疗早发性卵巢功能不全可以明显改善患者的临床症状,调节激素水平,提高治疗效果。

Objective: To observe the clinical effect of the therapy of catgut embedment in point combined with Yunzhong Jianpi decoction on premature ovarian insufficiency. Methods:A total of 80 cases with premature ovarian insufficiency were selected and divided into the Chinese medicine group and the combination group according to the random number table method, with 40 cases in each group. The Chinese medicine group was treated with Yunzhong Jianpi Decoction, and the combination group was additionally given catgut embedment in point based on the treatment of the Chinese medicine group. Both groups were treated for 12 weeks. The traditional Chinese medicine(TCM) syndrome scores and Symptom Check List-90(SCL-90) scores at different time points were compared between the two groups, the serum hormone levels at different time points were detected,and the clinical effects in the two groups were evaluated. Results:The total effective rate was 87.5% in the combination group,higher than that of70.0% in the Chinese medicine group, the difference being significance(P<0.05). After four, eight and twelve weeks of treatment, the scores of main symptoms and secondary symptoms in the two groups were decreased when compared with those before treatment(P<0.05);and the above scores in the combination group were lower than those in the Chinese medicine group at the same period respectively(P<0.05). After four, eight and twelve weeks of treatment, the SCL-90 scores in the two groups were decreased when compared with those before treatment(P<0.05);and the SCL-90 scores in the combination group were lower than those in the Chinese medicine group at the same period respectively(P<0.05). After four, eight and twelve weeks of treatment, levels of luteinizing hormone(LH), follicle stimulating hormone(FSH),progesterone(P) and testosterone(T) in the two groups were decreased when compared with those before treatment,and the levels of estradiol(E_(2)) and prolactin(PRL) were increased(P<0.05);the levels of LH, FSH and P in the combination group were lower than those in the Chinese medicine group at the same period respectively(P<0.05),and the E_(2) level in the combination group was higher(P<0.05). Conclusion: The therapy of catgut embedment in point combined with Yunzhong Jianpi Decoction for premature ovarian insufficiency can significantly improve the clinical symptoms of patients and adjust the hormone levels,with a better clinical effect.