血清甲状腺激素检测诊断甲状腺疾病的临床意义与价值

Clinical Significance and Value of Serum Thyroid Hormone Detection in the Diagnosis of Thyroid Diseases

目的探讨血清甲状腺激素检测诊断甲状腺疾病的临床意义与价值。方法150例甲状腺疾病患者按照诊断结果分为甲亢组与甲减组,另选择同期健康人员纳入对照组。检测三组的促甲状腺激素(TSH)、总甲状腺素(TT4)、游离甲状腺素(FT4)水平,分析上述检测指标对甲状腺疾病的诊断价值。结果甲亢组的TSH低于甲减组与对照组,TT4与FT4均高于甲减组与对照组(P<0.05);甲减组的TSH高于对照组,TT4与FT4低于对照组(P<0.05)。TSH、TT4、FT4联合检测诊断甲状腺疾病(甲亢与甲减)的灵敏度与特异性均高于三项指标单独检测(P<0.05)。结论甲亢与甲减患者患病过程中均伴随有血清甲状腺激素异常改变,多项实验室指标联合检测可提高疾病诊断的准确率。

Objective To explore the clinical significance and value of serum thyroid hormone detection in the diagnosis of thyroid diseases.Methods According to the diagnosis results,150 patients with thyroid diseases were divided into hyperthyroidism group and hypothyroidism group,and healthy people at the same period were selected as the control group.The levels of thyroid stimulating hormone(TSH),total thyroxine(TT4)and free thyroxine(FT4)of the three groups were detected,and the diagnostic value of the above detection indicators for thyroid diseases were analyzed.Results TSH in hyperthyroidism group was lower than that in hypothyroidism group and control group,and TT4 and FT4 were higher than those in hypothyroidism group and control group(P<0.05);TSH in hypothyroidism group was higher than that in control group,and TT4 and FT4 were lower than those in control group(P<0.05).The sensitivity and specificity of combined detection of TSH,TT4 and FT4 in the diagnosis of thyroid diseases(hyperthyroidism and hypothyroidism)were higher than those of single detection of the three indicators(P<0.05).Conclusions Patients with hyperthyroidism or hypothyroidism are accompanied by abnormal changes of serum thyroid hormones.The combined detection of multiple laboratory indicators can improve the accuracy of disease diagnosis.