丁螺环酮联合舍曲林治疗对伴有焦虑症状的抑郁症患者情绪变化及认知功能的影响

Impact of Buspirone Combined with Sertraline Treatment on Emotional Changes and Cognitive Function of Depression Patients with Anxiety Symptoms

目的探讨丁螺环酮联合舍曲林治疗对伴有焦虑症状的抑郁症患者情绪变化及认知功能的影响。方法80例伴有焦虑症状的抑郁症患者随机分为两组,对照组采用舍曲林治疗,观察组采用丁螺环酮联合舍曲林治疗,比较两组的情绪、认知功能及不良反应。结果治疗后,两组的HAMD、HAMA评分均较治疗前降低,MoCA评分均较治疗前升高(P<0.05);且与对照组相比,观察组的HAMD、HAMA评分均更低,MoCA评分更高(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论丁螺环酮联合舍曲林治疗可有效改善伴有焦虑症状抑郁症患者的负性情绪,提高患者的认知功能,且安全性较高。

Objective To explore the impact of buspirone combined with sertraline treatment on emotional changes and cognitive function of depression patients with anxiety symptoms.Methods 80 cases of depression patients with anxiety symptoms were randomly divided into two groups.The control group was treated with sertraline,and the observation group was treated with buspirone combined with sertraline.The emotions,cognitive function and adverse reactions were compared between the two groups.Results After treatment,the HAMD and HAMA scores of the two groups were lower than those before treatment,and the MoCA scores were higher than those before treatment(P<0.05);Compared with the control group,the HAMD and HAMA scores of the observation group were lower,and the MoCA score was higher(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Buspirone combined with sertraline treatment can effectively improve the negative emotions and improve the cognitive function of depression patients with anxiety symptoms,with high safety.