妊娠妇女甲状腺功能减退症发生情况及其影响因素分析

Analysis on the Occurrence and Influencing Factors of Hypothyroidism in Pregnant Women

目的分析妊娠妇女甲状腺功能减退症(甲减)的发生情况及其影响因素。方法选取2019年1月至2021年10月在我院产检的688例妊娠妇女,收集其一般资料及孕早期甲状腺功能检测结果,采用单因素和多因素Logistic回归分析探讨甲减发生的危险因素。结果688例妊娠妇女中,106例(15.41%)检出甲减。甲减组和非甲减组的年龄、BMI、妊娠次数、产次、生育间隔期、流产史、TPO-Ab阳性比例、TG-Ab阳性比例比较,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,高龄、经产、生育间隔期长、TPO-Ab阳性是妊娠期发生甲减的独立危险因素(P<0.05)。结论高龄、经产、生育间隔期长和TPO-Ab阳性是妊娠妇女发生甲减的独立危险因素,针对此类妊娠妇女应加强筛查和干预,避免不良妊娠结局的发生。

Objective To analyze the occurrence and influencing factors of hypothyroidism in pregnant women.Methods 688 pregnant women who underwent prenatal examination in our hospital from January 2019 to October 2021 were selected.The general data and thyroid function test results in early pregnancy were collected.Univariate analysis and multivariate Logistic regression analysis were used to explore the risk factors for the occurrence of hypothyroidism.Results Of the 688 pregnant women,106 cases(15.41%)had hypothyroidism.There were significant differences in age,BMI,number of pregnancies,parity,birth interval,abortion history,TPO-Ab positive proportion and TG-Ab positive proportion between hypothyroidism group and non-hypothyroidism group(P<0.05).multivariate Logistic regression analysis showed that advanced age,multiparity,long birth interval and TPO-Ab positive were independent risk factors for the occurrence of hypothyroidism during pregnancy(P<0.05).Conclusions Advanced age,multiparity,long birth interval and TPO-Ab positive are independent risk factors for the occurrence of hypothyroidism in pregnant women.Screening and intervention should be strengthened for such pregnant women to avoid the occurrence of adverse pregnancy outcomes.