应用3.0T磁共振IDEAL-IQ检测椎体骨髓脂肪分数诊断骨质疏松的效能评价

Efficacy evaluation of vertebral bone marrow fat fraction detected by 3.0T MRI IDEAL-IQ in diagnosis of osteoporosis

目的评价3.0T磁共振最小二乘估算法迭代水脂分离定量技术(IDEAL-IQ)检测椎体骨髓脂肪分数(FF)诊断骨质疏松的效能。方法选择2021年2月至2022年2月在该院进行健康体检者51名,其中男25名,女26名。采用双能X射线骨密度仪(DXA)检测骨密度值(T值),采用3.0T磁共振IDEAL-IQ检测椎体骨髓FF值,两项检查在同一天完成。以DXA检查结果将研究对象分为骨质正常组(T值≥-1.0 SD,25例)和骨质疏松组(T值≤-2.5 SD,26例)。比较两组FF值,并分析FF值与T值的相关性。采用ROC曲线评估FF值诊断骨质疏松的效能。结果与骨质正常组相比,骨质疏松组年龄、FF值较大,T值较小,差异有统计学意义(P<0.05)。Spearman秩相关分析结果显示,FF值与T值呈负相关(r_(s)=-0.642,P<0.001)。ROC曲线分析结果显示,FF值可用于诊断骨质疏松[AUC(95%CI)=0.922(0.879~0.965),P<0.001],最佳截断值为50.42%,其对应的灵敏度为88.10%,特异度为82.60%。结论3.0T磁共振IDEAL-IQ检得椎体骨髓FF值与T值呈负相关,具有诊断骨质疏松症的应用价值。

Objective To evaluate the efficacy of vertebral bone marrow fat fraction(FF)detected by 3.0T magnetic resonance imaging(MRI)iterative decomposition of water and fat with echo asymmetrical and least-squares estimation quantitation sequence(IDEAL-IQ)in diagnosis of osteoporosis.Methods Fifty-one healthy people undergoing physical examination in Zhongshan Hospital,Fudan University(Xiamen Branch)from February 2021 to February 2022 were selected,including 25 males and 26 females.Bone mineral density(T value)was measured by dual-energy X-ray absorptiometry(DXA)and vertebral bone marrow FF value was measured by 3.0T MRI IDEAL-IQ on the same day.According to the results of DXA examination,the study subjects were divided into normal bone group(T value≥-1.0 SD,25 cases)and osteoporosis group(T value≤-2.5 SD,26 cases).FF value was compared between the two groups,and the correlation between FF value and T value was analyzed.Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of FF value in the diagnosis of osteoporosis.Results Compared with the normal bone group,the osteoporosis group had older age and larger FF value,and smaller T value,with statistically significant differences between the two groups(P<0.05).The results of Spearman rank correlation showed that FF value was negatively correlated with T value(r_(s)=-0.642,P<0.001).The results of ROC curve analysis showed that FF value can be used to diagnose osteoporosis[AUC(95%CI)=0.922(0.879-0.965),P<0.001].The best cutoff value was 50.42%,and its corresponding sensitivity and specificity were 88.10%and 82.60%,respectively.Conclusion The FF value of vertebral bone marrow detected by 3.0T MRI IDEAL-IQ is negatively correlated with T value,which has the application value in the diagnosis of osteoporosis.