基于中西医临床病证特点的系统性红斑狼疮动物模型研究评述

Systematic Review of Animal Models of Systemic Lupus Erythematosus Based on the Clinical Features of Traditional Chinese and Western Medicine

基于系统性红斑狼疮(SLE)的中西医临床病证特点,参考国内外SLE动物模型研究文献,依据临床诊断标准,对现有模型的临床符合度进行评价,经对比分析发现,自发小鼠模型中的MRL/lpr小鼠模型与诱导模型中的姥鲛烷诱导模型中西医临床病证吻合度最高。但目前SLE动物模型多按照西医病因特点建模,缺乏中医病证结合模型,中医符合度低,因此在现有研究基础上增加中医干扰因素,彰显中医辨证优势,加强SLE中医辨证相关研究是今后努力的方向。

Based on the clinical features of systemic lupus erythematosus(SLE) in traditional Chinese medicine(TCM) and western medicine and the research literature of animal models of SLE in China and abroad, the present study evaluated the clinical coincidence of existing models according to clinical diagnostic criteria.The comparative analysis indicated that the MRL/lpr mouse model among spontaneous mouse models and the pristane-induced model among induced models had the highest coincidence of clinical disease and syndrome of TCM and western medicine.At present, however, SLE animal models are mostly induced based on the etiological characteristics of western medicine, lacking the TCM characteristics of a combination of disease and syndrome, and the coincidence in TCM is low.Therefore, on the basis of existing research, increasing the TCM intervention factors, highlighting the advantages of TCM syndrome differentiation, and strengthening the relevant research on TCM syndrome differentiation of SLE are the focuses of follow-up research.