健胃消食口服液联合酪酸梭菌活菌散治疗小儿功能性消化不良的临床研究

Clinical study of Jianwei Xiaoshi Oral Liquid combined with Clostridium Butyricum Powders in treatment of functional dyspepsia in children

目的 探讨健胃消食口服液联合酪酸梭菌活菌散治疗小儿功能性消化不良的临床疗效。方法 选取2017年1月—2020年7月南京医科大学附属儿童医院门诊就诊的120例小儿功能性消化不良患儿,按照随机数字表法将所有患儿分为对照组和治疗组,每组各60例。对照组口服酪酸梭菌活菌散,1包/次,3次/d。治疗组在对照组治疗基础上口服健胃消食口服液,10 mL/次,2次/d。两组患儿均连续治疗14 d。观察两组的临床疗效,比较两组临床症状缓解时间、功能性消化不良生存质量表(FDDQL)评分、血浆胃泌素(GAS)、血浆胃动素(MTL)、血浆P物质(SP)。结果 治疗后,治疗组总有效率98.33%,显著高于对照组的85.00%(P<0.05)。治疗后,治疗组出现腹胀、厌食、嗳气、反酸改善时间均显著短于对照组(P<0.05)。治疗后,两组FDDQL评分均较治疗前显著升高(P<0.05);治疗后治疗组FDDQL评分高于对照组(P<0.05)。治疗后,两组患儿GAS、MTL、SP水平均较治疗前显著升高(P<0.05);治疗后,治疗组胃肠激素指标水平显著高于对照组(P<0.05)。结论 健胃消食口服液联合酪酸梭菌活菌散治疗小儿功能性消化不良效果确切,能有效调节患儿胃肠激素水平,更利于患儿生活质量的改善,值得借鉴。

Objective To investigate the clinical efficacy of Jianwei Xiaoshi Oral Liquid combined with Clostridium Butyricum Powders in treatment of functional dyspepsia in children. Methods A total of 120 children with functional dyspepsia admitted to the Children’s Hospital of Nanjing Medical University from January 2017 to July 2020 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Children in the control group were po administered with Clostridium Butyricum Powders, 1 bag/time, three times daily. Patients in the treatment group were po administered with Jianwei Xiaoshi Oral Liquid on the basis of the control group, 10 mL/time, twice daily. Both groups were treated for 14 d. The clinical efficacy of the two groups was observed, and the clinical symptom remission time, FDDQL score, plasma gastrin(GAS),plasma motilin(MTL) and plasma substance P(SP) were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.33%, which was significantly higher than that of the control group(85.00%, P < 0.05).After treatment, the improvement time of abdominal distension, anorexia, belching and acid regurgitation in the treatment group was significantly shorter than that in the control group(P < 0.05). After treatment, FDDQL scores in both groups were significantly higher than before treatment(P < 0.05). After treatment, the FDDQL score of the treatment group was higher than that of the control group(P < 0.05). After treatment, GAS, MTL, and SP levels in two groups were significantly increased compared with before treatment(P <0.05). After treatment, gastrointestinal hormone indexes in the treatment group were significantly higher than those in the control group(P < 0.05). Conclusion Jianwei Xiaoshi Oral Liquid combined with Clostridium Butyricum Powders has exact effect in treatment of functional dyspepsia in children, and can effectively regulate the level of gastrointestinal hormone in children, and improve the quality of life of children, which is worth learning.