脑肠肽Ghrelin对肠道缺血再灌注保护作用的研究进展

Research progress of the protective effects of Ghrelin on intestinal ischemia/reperfusion injury

肠道缺血再灌注损伤是临床上常见的危重症之一,常常威胁着病人生命。脑肠肽Ghrelin是生长激素促分泌物受体的内源性配体,可促进生长激素的释放。近年多项研究发现Ghrelin在肠道缺血再灌注损伤中亦起到保护作用。探究Ghrelin对肠道缺血再灌注损伤的保护作用及相关机制,从而指导临床诊疗对于肠道缺血再灌注损伤病人预后有着极为重要的意义。本文将对Ghrelin对肠道缺血再灌注损伤的保护作用予以综述,为寻找新的诊治方法提供新思路。

Intestinal ischemia/reperfusion injury is one of the common critical diseases in clinical practice,which often threatens patients’lives.Ghrelin is an endogenous ligand of growth hormone secretory receptor,which could promote the release of growth hormone.A great deal of studies have found that Ghrelin also plays a protective role in intestinal ischemia/reperfusion injury in recent years.It is of great significance to explore the protective effects and the related mechanism of Ghrelin on intestinal ischemia/reperfusion injury so as to guide clinical diagnosis and treatment for the prognosis of patients with intestinal ischemia/reperfusion injury.We will review the protective effects of Ghrelin on intestinal ischemia/reperfusion injury,providing new ideas for finding new diagnosis and treatment methods in this article.