肌肉减少症与结直肠癌关系的研究进展

Research progress on the relationship between sarcopenia and colorectal cancer

肌肉减少症是一种以骨骼肌质量和力量的进行性和全身性丧失为特征的综合征,导致身体残疾、生活质量降低甚至死亡。发生机制涉及炎症和氧化应激、激素水平改变、线粒体功能障碍等。结直肠癌病人肌肉减少症的发生率在12%~60%之间。有研究表明,肌肉减少症可能对CRC病人围术期产生负面影响而导致不良临床结局。本综述结合国内外最新研究进展,系统阐述CRC病人肌肉减少症的发生机制、评估方法、以及对围术期并发症、化疗毒副作用和生存预后的影响,总结并展望CRC病人肌肉减少症的干预措施。

Sarcopenia is a syndrome characterized by progressive and systemic loss of skeletal muscle mass and strength,leading to physical disability,reduced quality of life and even mortality.The mechanism of sarcopenia involves inflammation and oxidative stress,changes in hormone levels,and mitochondrial dysfunction.The prevalence of sarcopenia in patients with colorectal cancer(CRC)ranges from 12%to 60%.Studies have shown that sarcopenia may have a negative impact during the perioperative period of CRC surgery and lead to adverse postoperative outcomes.Based on the latest research progress,this review systematically elaborates the mechanism,evaluation methods,and effects of sarcopenia on perioperative complications,toxicity and side effects of chemotherapy and long-term survival in CRC patients,and summarizes and proposes the treatment strategy for sarcopenia in such population.