免疫抑制治疗在脓毒血症治疗中的作用

Effects of immunosuppressive therapy on treatment of sepsis

脓毒血症主要是由异物感染引起的宿主免疫反应失调,进而发展为威胁生命的器官功能障碍。一般认为脓毒血症的发病机制是由最开始的持续性炎症反应中的炎症激活发展为最终的免疫抑制反应中免疫功能缺陷,打破了机体免疫平衡。本文就脓毒血症患者持续过激炎症和免疫抑制动态平衡的重要性及相应治疗进展进行综述。

Sepsis is a disorder of host immune response primarily caused by external infections with further development of life-threatening organ dysfunction.Generally,pathogenesis of sepsis is from initial inflammatory activation in persistent inflammatory response to final immunosuppression of immune function of deficiency,which breaks balance of immune response.This article focuses on signification of dynamic balance between persistent inflammation and immunosuppression in sepsis patients and corresponding treatment progress of sepsis.