miRNA在原发性肾小球疾病诊断及治疗中应用的研究进展

Application of miRNA in primary glomerular disease diagnosis and treatment

原发性肾小球疾病已经成为重要的公共卫生问题,最终会发展为终末期肾病(ESRD),给患者本人、家庭及社会都带来巨大负担。微小RNA(miRNA)的差异表达具有辅助疾病诊断、反映疾病严重程度及预后的潜力,为原发性肾小球疾病的早诊早治提供可能。本文将对近些年miRNAs在IgA肾病、特发性膜性肾病等原发性肾小球疾病诊疗中的研究进展进行综述。

Primary glomerulopathy has become an important public health issue in recent years.End-stage renal disease(ESRD)will occur in later stage of the disease,which bring huge burdens on individuals,families and society.Differential expression of micro RNA(miRNA)has potential to assist in the diagnosis,reflect the severity and prognosis,and provide possibility for early diagnosis and treatment of primary glomerular diseases.This article will review the application of miRNAs in diagnosis and treatment of primary glomerular diseases such as IgA nephropathy and idiopathic membranous nephropathy.