血脑屏障和中枢神经系统疾病相关性的研究进展

Research progress on the relationship between blood brain barrier and central nervous system diseases

中枢神经系统接受全身各处的传入信息,经中枢神经系统整合加工后成为协调的运动传出,或者储存在中枢神经系统内成为学习、记忆的神经基础.中枢神经系统易受到致病因素影响而发生以精神活动障碍为主要表现的疾病,同时亦可出现中枢神经系统退行性病变.而血脑屏障能够使脑组织少受甚至不受循环血液中有害物质的损害,从而保持脑组织内环境的基本稳定,对维持中枢神经系统正常生理状态具有重要的生物学意义.对血脑屏障与中枢神经系统疾病相关性的研究进展进行总结与综述,以期为中枢神经系统疾病的预防与治疗提供更新与更全面的理论基础.

The central nervous system receives the input information from all parts of the body,and becomes a coordinated motor outflow after the integration and processing of the central nervous system,or stored in the central nervous system to become the neural basis of learning and memory.Central nervous system is easy to be affected by pathogenic factors,and the main manifestation is mental disorders.At the same time,central nervous system degeneration can also occur.The blood-brain barrier can make the brain tissue less or even not damaged by harmful substances in the circulating blood,thus maintaining the basic stability of the brain tissue,which has important biological significance for maintaining the normal physiological state of the central nervous system.This paper summarizes and reviews the research progress of the relationship between blood-brain barrier and central nervous system diseases,in order to provide a new and more comprehensive theoretical basis for the prevention and treatment of central nervous system diseases.