宫腹腔镜联合黑泥鳅导丝介入治疗输卵管性不孕症的临床效果

Clinical effect of hysteroscopy and laparoscopy combined with black loach guide wire intervention in the treatment of tubal infertility

目的探讨宫腹腔镜联合黑泥鳅导丝介入治疗输卵管性不孕症的临床效果。方法选择2017年7月至2020年1月我院妇产科收诊的120例输卵管性不孕症患者,将其随机分为对照组(60例,腹腔镜下子宫输卵管通液术)和观察组(60例,宫腹腔镜联合黑泥鳅导丝介入)。比较两组的治疗效果。结果观察组的手术时间、住院时间短于对照组,术中出血量少于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。术后7 d,观察组的肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平低于对照组(P<0.05)。观察组的术中疏通率及术后输卵管通畅率、受孕率高于对照组,术中输卵管破裂出血发生率低于对照组(P<0.05)。术后7 d,观察组的C反应蛋白(CRP)、肾上腺素(E)、皮质醇(Cor)水平低于对照组(P<0.05)。术后3个月,观察组的健康调查简表(SF-36)各维度评分高于对照组(P<0.05)。结论宫腹腔镜联合黑泥鳅导丝介入治疗输卵管性不孕症,可缩短手术时间,减少术中出血量,提高治疗总有效率及患者的生活质量,值得临床推广。

Objective To explore the clinical effect of hysteroscopy and laparoscopy combined with black loach guide wire intervention in the treatment of tubal infertility.Methods A total of 120 patients with tubal infertility admitted in the gynecology and obstetrics department of our hospital from July 2017 to January 2020 were randomly divided into control group(60 cases,laparoscopic uterine tubal hydrotubation)and observation group(60 cases,hysteroscopy and laparoscopy combined with black loach guide wire intervention).The therapeutic effects of the two groups were compared.Results The operation time and hospitalization time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).At 7 d after operation,the levels of tumor necrosis factor-α(TNF-α),interleukin-4(IL-4)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).The intraoperative dredging rate,postoperative tubal patency rate and pregnancy rate of the observation group were higher than those of the control group,and the incidence of intraoperative tubal rupture and bleeding was lower than that of the control group(P<0.05).At 7 d after operation,the levels of C-reactive protein(CRP),epinephrine(E)and cortisol(Cor)in the observation group were lower than those in the control group(P<0.05).Three months after operation,the scores of 36-item Short From Health Survey(SF-36)dimensions in the observation group were higher than those in the control group(P<0.05).Conclusion Hysteroscopy and laparoscopy combined with black loach guide wire intervention in the treatment of tubal infertility can shorten the operation time,reduce intraoperative blood loss,improve the total effective rate of treatment and the quality of life of patients,which is worthy of clinical application.