特发性弱精症的研究进展

Research progress of idiopathic asthenospermia

不明原因的精子活力低下称为特发性弱精症。其发病机制可能与基因突变、基因多态性、蛋白质差异表达、启动子异常甲基化及精浆塑化剂等有关,但相关研究仍没有一致的结论。近年来,特发性弱精症逐渐成为国内外研究的热点,本文现从基因组学(基因突变、基因表达异常、基因多态性、遗传保护因素)、蛋白组学及其他因素等3个方面进行综述,为临床治疗与相关研究提供参考依据。

Unexplained low sperm motility is called idiopathic asthenospermia. The pathogenesis may be related to gene mutation, gene polymorphism, the differential expression of protein, abnormal methylation of promoter, plasticizer of seminal plasma, etc., but relevant studies have not reached consistent conclusions. In recent years, idiopathic asthenospermia has gradually become a hot topic of research at home and abroad. This article summarized the genomics(gene mutation, abnormal gene expression, gene polymorphism, genetic protective factors), proteomics and other factors, in order to provide reference for clinical treatment and related research.