戊酸雌二醇片结合来曲唑治疗排卵功能障碍致不孕症的疗效及对卵泡发育、排卵的影响

Effect of estradiol valerate tablets combined with letrozole on infertility caused by ovulation dysfunction and its effect on follicular development and ovulation

目的 研究戊酸雌二醇片结合来曲唑治疗排卵功能障碍致不孕症的疗效及对卵泡发育、排卵情况的影响。方法 选取2021年1月至12月在诸暨市妇幼保健院进行治疗的120例不孕症患者作为研究对象,随机分为观察组和对照组,各60例,所有患者均采取来曲唑治疗,观察组在此基础上联合采用戊酸雌二醇片进行治疗,两组均治疗8周。比较两组治疗效果、性激素水平、卵泡发育情况及不良反应的差异。结果 观察组总有效率显著高于对照组(P<0.05);治疗后,两组孕酮(P)、卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)水平均显著下降,雌二醇(E_(2))水平显著上升,且观察组P、FSH、T、LH水平显著低于对照组,E2水平显著高于对照组(P<0.05);观察组成熟卵泡直径、子宫内膜厚度显著高于对照组,卵泡排出时间显著短于对照组(P<0.05);治疗后,两组最大流率(Vmax)、阻力指数(RI)均显著改善,且观察组RI显著低于对照组,Vmax显著高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 戊酸雌二醇片结合来曲唑治疗排卵功能障碍致不孕症疗效确切,能够促进卵泡发育,改善排卵情况。

Objective To study the effect of estradiol valerate tablets combined with letrozole on infertility caused by ovulation dysfunction and its effect on follicular development and ovulation. Methods 120 infertility patients treated in Zhuji Maternal and Child Health Hospital from January to December 2021 were randomly divided into the observation group and the control group, 60 cases in each group. All patients were treated with letrozole, and the observation group was treated with estradiol valerate tablets on this basis. Both groups were treated for 8 weeks. The therapeutic effect, hormone levels, follicle development and adverse reactions were compared between the two groups. Results The overall effective rate of observation group was significantly higher than that of control group(P<0.05). After treatment, progesterone(P), follicle stimulating hormone(FSH), testosterone(T) and luteinizing hormone(LH) in the two groups were significantly decreased, while estradiol(E_(2)) was significantly increased;P, FSH, T and LH of observation group were significantly lower than that of control group, E2was significantly higher than that of control group(P<0.05). Mature follicle diameter, endometrial thickness of observation group were significantly higher than that of control group, ovarian eduction time was significantly shorter than that of control group(P<0.05). After treatment, Vmax and RI of both groups were significantly improved, and RI of observation group was significantly lower than that of control group, Vmax was significantly higher than that of control group(P<0.05). There was no statistical significance in the level of adverse reactions between the two groups(P>0.05). Conclusions Estradiol valerate tablet combined with letrozole is effective in the treatment of infertility caused by ovulation dysfunction. It can promote follicular development and improve ovulation.