摘要
NK细胞在异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)中具有抗肿瘤及抗感染作用,移植后NK细胞在功能重建过程中功能的获得与否主要依赖于NK细胞的教育。allo-HSCT是研究NK细胞教育的良好模型,文章将从NK细胞教育学说、NK细胞教育对NK细胞功能的调控以及移植过程中可能影响NK细胞教育的不同因素进行综述。
NK cell plays the role of anti-tumor and anti-infection in allogeneic hematopoietic stem cell transplantation(allo-HSCT).NK cell functionalization after hematopoietic reconstruction mainly depends on the education of NK cell.allo-HSCT provides a good model for studying NK cell education.This paper will summarize the NK cell education theory,the regulation of NK cell education on NK cell function,and the different factors that may affect NK cell education during transplantation.
作者
徐郑丽
赵翔宇
XU Zheng-li;ZHAO Xiang-yu(Peking University People's Hospital,Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China)
出处
《现代免疫学》
CAS
北大核心
2023年第1期54-59,共6页
Current Immunology
基金
国家自然科学基金面上项目(81670166,81870140,82070184)
国家自然科学基金青年项目(82100227)。
