Bio-Oss骨粉联合PRF及GBR技术对种植体周围骨再生及种植体周围炎的影响

Effects of Bio-Oss Bone Meal Combined with PRF and GBR Technologyon Peri-Implant Bone Regeneration and Peri-Implantitis

目的:探究Bio-Oss骨粉联合PRF及GBR技术对种植体周围骨再生及种植体周围炎的影响。方法:选取2020年2月至2022年4月期间于本院行口腔种植引导性骨再生术的90例患者为研究对象,依据入院先后顺序分为三组。Bio-Oss组30例予以Bio-Oss骨粉联合引导性骨再生技术(GBR)引导再生,PRF组30例予以富血小板纤维蛋白(PRF)联合GBR技术引导再生;联合组30例予以Bio-Oss骨粉联合PRF及GBR技术引导再生。比较三组术后1个月、3个月种植体周围骨再生情况、术后24h疼痛情况、术后1周术区黏膜肿胀情况、以及术前、术后1个月、3个月的菌斑指数(PLI)、探查深度(PD),并对比三组术后并发症发生情况。结果:术后1个月、3个月,联合组的植骨高度、成骨厚度均显著高于Bio-Oss组及PRF组(P<0.05),Bio-Oss组、PRF组植骨高度、成骨厚度比较差异不明显(P>0.05);术后24h,联合组的疼痛情况明显优于其他两组(P<0.05),而其余两组间比较差异不显著(P>0.05)。术后1周,联合组术区黏膜肿胀度明显轻于Bio-Oss组及PRF组(P<0.05),而Bio-Oss组、PRF组间比较差异不显著(P>0.05)。术后1个月、3个月,三组PLI、PD均较术前明显降低(P<0.05);且联合组PLI评分、PD显著低于Bio-Oss组和PRF组(P<0.05),而PRF组与Bio-Oss组比较差异不明显(P>0.05)。三组术后并发症总发生率比较差异不明显(P>0.05)。结论:口腔种植引导性骨再生术中应用Bio-Oss骨粉联合PRF及GBR技术有助于促进术后骨缺损再生,减轻术后疼痛,促进软组织再生,减轻黏膜肿胀,促进种植体周围软组织炎症明显好转,且安全性高,值得临床推广应用。

Objective:To explore the effect of Bio-Oss bone meal combined with PRF and GBR technology on peri-implant bone regeneration and peri-implantitis.Methods:A total of 90 patients who underwent oral implant-guided bone regeneration in our hospital from February 2020 to April 2022 were selected as the research subjects,and divided into 3 groups according to the order of admission.Thirty cases in the Bio-Oss group were given Bio-Oss bone meal combined with guided bone regeneration(GBR)for guided regeneration,30 cases in the PRF group were given platelet-rich fibrin(PRF)combined with GBR technique for guided regeneration,and 30 cases in the combined group were given Bio-Oss bone meal Combined PRF and GBR technology to guide regeneration.The peri-implant bone regeneration at 1 month and 3 months after operation among the three groups,pain at 24 hours after the operation,mucosal swelling at the surgical site at 1 week after the operation,and the plaque index(PLI)before surgery,1 month,and 3 months after surgery probing depth(PD),and postoperative complications were compared among the three groups.Results:At 1 month and 3 months after the operation,the height of the bone graft and the thickness of bone formation in the combined group were significantly higher than those in the Bio-Oss group and the PRF group(P<0.05).There was no significant difference in the bone graft height and bone formation thickness between the Bio-Oss group and the PRF group(P>0.05);24 hours after the operation,the pain in the combined group was significantly better than that in the other two groups(P<0.05),while there was no significant difference between the other two groups(P>0.05).One week after the operation,the mucosal swelling in the combined group was significantly lighter than that in the Bio-Oss group and the PRF group(P<0.05),while there was no significant difference between the Bio-Oss and PRF groups(P>0.05).At 1 month and 3 months after the operation,the PLI and PD of the three groups were significantly lower than those before the operation(P<0.05).And the PLI score and PD of the combined group were significantly lower than those of the Bio-Oss group and the PRF group(P<0.05).However,there was no significant difference between the PRF group and the Bio-Oss group(P>0.05).There was no significant difference in the total incidence of postoperative complications among the three groups(P>0.05).Conclusion:The application of Bio-Oss bone powder combined with PRF and GBR technology in oral implant-guided bone regeneration can help promote postoperative bone defect regeneration,reduce postoperative pain,promote soft tissue regeneration,reduce mucosal swelling,and promote obvious peri-implant soft tissue inflammation improved,and the safety is high,which is worthy of clinical application.