不同剂次糠酸莫米松乳膏治疗儿童严重生理性包茎的临床效果比较

Comparison of clinical effects of different doses of mometasone furoate cream in the treatment of children’s serious physiological phimosis

目的比较每天不同剂次外用0.1%糠酸莫米松乳膏治疗儿童严重生理性包茎的疗效。方法选取2018年4月至2021年4月该院门诊治疗的严重包茎患儿(Kikiros分类4~5级)605例作为研究对象。患儿年龄3~11岁,采用随机数字表法分为观察组303例和对照组302例。两组均予以0.1%糠酸莫米松乳膏外涂包皮口,观察组每晚1次、持续4周,对照组早晚各1次、持续4周。比较两组患儿在治疗开始后的2周、4周、3个月复诊的有效率(Kikiros分类0~1级)。结果观察组完成治疗278例,治疗后2周、4周和3个月治疗有效率分别为33.5%、69.8%和64.7%;对照组完成治疗264例,治疗后2周、4周、3个月治疗有效率分别为44.7%、70.8%和66.3%。观察组治疗后2周有效率低于对照组(P<0.05),而两组治疗后4周、3个月有效率比较差异无统计学意义(P>0.05)。观察组、对照组分别有5、7例出现药物不良反应。结论每天1、2次连续4周外用类固醇治疗严重包茎均可获得满意疗效,其适用于要求保守治疗的儿童。

Objective To compare the efficacy of 0.1%mometasone furoate cream in treating serious physiological phimosis in children with different doses every day.Methods A total of 605 cases of severe phimosis(Kikiros classification 4~5)were selected from April 2018 to April 2021 as the research objects.The children aged 3 to 11 years old were divided into observation group(303 cases)and control group(302 cases).Both groups were coated with 0.1%mometasone furoate cream.The observation group was treated once every night for four weeks,while the control group was treated once every morning and evening for four weeks.The effective rate of follow-up in the second week,the fourth week and the third month after the start of treatment was compared between the two groups(Kikiros classification 0-1).Results The observation group completed 278 cases,and the effective rates of treatment in the second week,the fourth week and the third month after treatment were 33.5%,69.8%and 64.7%,respectively.The control group completed 264 cases,and the effective rates of treatment in the second week,the fourth week and the third month after treatment were 44.7%,70.8%and 66.3%,respectively.The effective rate of the observation group in the second week after treatment was lower than that in the control group(P<0.05),but there was no statistical difference between the two groups in the fourth week and the third month after treatment(P>0.05).There were five cases of adverse drug reactions in the observation group and seven cases in the control group.Conclusion External application of steroids once or twice a day for four weeks can achieve satisfactory results in the treatment of severe phimosis,and it is suitable for children who require conservative treatment.