精神分裂症和抑郁症患者外周全血细胞计数的相关分析

Correlation Analysis of Peripheral Complete Blood Cell Counts in Patients With Schizophrenia and Depression

目的对精神分裂症与抑郁症患者的外周全血细胞计数等指标进行检测,以健康患者作为参考依据,观察各指标水平在两种疾病中的变化情况。方法在2020年8月—2022年8月,将龙岩市第三医院检验科收治的精神分裂症50例患者纳入分裂组,50例抑郁症患者纳入抑郁组,同时将同期选择50例健康体检患者纳入健康组,对全部纳入对象的全细胞计数指标进行检测,检测工具为全自动血细胞分析仪,观察三组患者的白细胞计数(leucocyte count,WBC)、中性粒细胞(neutrophile granulocyte,NE)百分比、淋巴细胞(lymphocyte,LYM)、红细胞计数(red-cell count,RBC)、血红蛋白浓度(hemoglobin concentration,HGB)、红细胞体积分布宽度(red blood cell volume distribution width,RDW)、血小板计数(platelet count,PLT)。结果与健康组相比,分裂组、抑郁组患者的WBC、NE百分比、LYM百分比更高,差异有统计学意义(P<0.05)。分裂组与抑郁组患者WBC、NE百分比、LYM百分比相较差异无统计学意义(P>0.05)。与健康组相比,分裂组、抑郁组患者的RDW、RBC、HGB指标水平更高,差异有统计学意义(P<0.05)。分裂组与抑郁组患者RDW、RBC、HGB相较差异无统计学意义(P>0.05)。三组患者PLT水平相较差异无统计学意义(P>0.05)。结论精神分裂症与抑郁症患者的外周全血细胞计数水平均异于正常人,两种疾病上述指标水平有相似的临床变化,提示患者体内不仅存在隐性感染与慢性炎症,而且同时存在血液营养成分减低的现象,临床诊疗过程中应对此现象引起重视。

Objective The peripheral complete blood cell count of patients with schizophrenia and depression was tested,and the healthy patients were used as a reference to observe the change of each index level in the two diseases.Methods From August 2020 to August 2022,50 patients with schizophrenia admitted to the department of laboratory,Three Hospital of Longyan were included in the schizoaffective group,50 patients with depression were included in the depression group,and 50 patients with physical examination were selected to be included in the healthy group during the same period.The whole cell count index of all included subjects was tested using automatic blood cell analyzer.The leucocyte count(WBC),neutrophile granulocyte(NE)percentage,lymphocyte(LYM)count,red-cell count(RBC),hemoglobin concentration(HGB),red blood cell volume distribution width(RDW)and platelet count(PLT)were observed in the three groups.Results Compared with the healthy group,the percentages of WBC,NE and LYM in the schizoaffective group and the depressed group were higher,and the differences were statistically significant(P<0.05).There were no significant differences in the percentage of WBC,NE and LYM between split group and depression group(P>0.05).Compared with the healthy group,the RDW,RBC and HGB indexes in the schizoaffective group and the depressed group were higher,and the differences were statistically significant(P<0.05).There was no significant difference in RDW,RBC and HGB between schizoaffective group and depression group(P>0.05).There was no significant difference in PLT level among the three groups(P>0.05).Conclusion Schizophrenia and depression patients with peripheral whole blood cell count levels are different from normal people,the two diseases have similar clinical changes,suggest patients body not only exist recessive infection and chronic inflammation,and at the same time the blood nutrition reduction phenomenon,clinical treatment should pay attention to this phenomenon.