干燥综合征患者肠道菌群特点研究

Characteristics of intestinal flora in patients with sjogren syndrome

目的探讨干燥综合征(SS)患者的肠道菌群的分布特征。方法选取2022年1-6月该院收治的SS患者10例作为病例组,另选取同期健康体检的志愿者10例作为健康组。采集两组研究对象粪便,取16S V4区引物进行测定,鉴定两组研究对象肠道细菌的多样性。结果两组研究对象肠道菌群丰富度比较,差异有统计学意义(P<0.05);两组研究对象菌群多样性比较,差异无统计学意义(P>0.05)。结论SS与健康者表现出明显的肠道菌群差异,为此加强肠道菌群的调节在预防和控制SS方面具有重要意义。

Objective To investigate the distribution of intestinal flora in patients with Sjogren's syndrome(SS).Methods 10 patients with SS admitted in our hospital from January 2022 to June 2022 were selected as the case group,and 10 healthy volunteers in the same period were selected as the control group.The feces of the two groups were collected,and 16S V4 primers were taken for determination to identify the bacterial diversity of the two groups.Results There was significant difference in the richness of intestinal flora between the two groups(P<0.05),and there was no significant difference in the diversity of intestinal flora(P>0.05).Conclusion SS and healthy people show significant differences in intestinal flora.Therefore,strengthening the regulation of intestinal flora is of great significance in the prevention and control of SS diseases.